ZBTB1 - zinc finger and BTB domain containing 1 Gene

Also Known as ZNF909

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22890

About ZBTB1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,503,716-64,533,693 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 14.1), lymph node (RPKM 11.3) and 25 other tissues.

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including cellular response to UV; nucleobase-containing compound biosynthetic process; and protein homooligomerization. Located in centrosome; nuclear body; and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB1 Products (2)

mRNA Protein Name
NM_001123329.2 NP_001116801.1 zinc finger and BTB domain-containing protein 1 isoform 1
NM_014950.3 NP_055765.2 zinc finger and BTB domain-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
24657165 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
22753936 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
22753936 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
24657165 GOA
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
24657165 GOA
involved in cellular response to UV IMP
IMP: Inferred from mutant phenotype
24657165 GOA
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
24657165 GOA
involved in mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21706167 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20797634 GOA
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
20797634 GOA
involved in translesion synthesis IMP
IMP: Inferred from mutant phenotype
24657165 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear body IDA
IDA: Inferred from direct assay
20797634 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
20797634 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21706167 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB1 Protein Structure

BTB

BTB: BTB/POZ domain (14 - 115)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (534 - 556)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (592 - 616)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (663 - 684)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (686 - 709)

  • 0
  • 200
  • 400
  • 600
  • 713 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 1

ZBTB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB1 Q9Y2K1 PIM1 Homo sapiens P11309
Y2H Array
25416956
Intra
ZBTB1 Q9Y2K1 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra
ZBTB1 Q9Y2K1 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
ZBTB1 Q9Y2K1 AKR7A2 Homo sapiens O43488
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15959 ZBTB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19496 Zbtb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25990 Zbtb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZBTB1 VGNC VGNC:37057
Canis familiaris ZBTB1 VGNC VGNC:48519
Felis catus ZBTB1 VGNC VGNC:67160
Rattus norvegicus ZBTB1 RGD RGD:1303095
Mus musculus ZBTB1 MGD MGI:2442326
Macaca mulatta ZBTB1 VGNC VGNC:79238
Others ZBTB1 NCBI