1. Gene
  2. PIM1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

PIM1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

Homo sapiens

Also known as PIM

Gene ID: 5292 | Gene type: protein coding

About PIM1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,170,152-37,175,428 (from NCBI)

This gene has 3 transcripts (splice variants), 245 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in bone marrow (RPKM 89.3), esophagus (RPKM 60.8) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and Pim subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate Cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

PIM1 Products(2)

mRNA Protein Name
NM_001243186.2 NP_001230115.1 serine/threonine-protein kinase pim-1 isoform 1
NM_002648.4 NP_002639.1 serine/threonine-protein kinase pim-1 isoform 2

PIM1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (38 - 290)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-1

Oncogene PIM1

pim-1 oncogene (proviral integration site 1)

proto-oncogene serine/threonine-protein kinase pim-1

Related Diseases

Diseases Alias
Primary Central Nervous System Lymphoma

Pcnsl

Primary Cns Lymphoma

Primary Brain Lymphoma

Primary Lymphoma, Cns

Primary Cerebral Lymphoma

Plasma Protein Metabolism Disease
Dressler'S Syndrome

Dressler Syndrome

Postmyocardial Infarction Syndrome

Donath-Landsteiner Hemolytic Anemia

Post-Myocardial Infarction Syndrome

Postmyocardial Infarction Pericarditis

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Polyploidy

Polyploid

Polyploidy Syndrome

Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PIM1 VGNC VGNC:32899
Rattus norvegicus PIM1 RGD RGD:3330
Felis catus PIM1 VGNC VGNC:102483
Mus musculus PIM1 MGD MGI:97584
Others PIM1 NCBI