1. JAK/STAT Signaling
  2. Pim
  3. PIM447

PIM447 (Synonyms: LGH447)

Cat. No.: HY-19322
Handling Instructions

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.

For research use only. We do not sell to patients.

PIM447 Chemical Structure

PIM447 Chemical Structure

CAS No. : 1210608-43-7

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Description

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. target: pan-PIM inhibitor [2] [3] In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.[1] In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma.[1]

Clinical Trial
Molecular Weight

440.46

Formula

C₂₄H₂₃F₃N₄O

CAS No.

1210608-43-7

SMILES

O=C(C1=CC=C(F)C(C2=C(F)C=CC=C2F)=N1)NC3=C([[email protected]@H]4C[[email protected]](C)C[[email protected]](N)C4)C=CN=C3

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