1. JAK/STAT Signaling
  2. Pim
  3. PIM-447 dihydrochloride

PIM-447 dihydrochloride (Synonyms: LGH447 dihydrochloride)

Cat. No.: HY-19322B Purity: 99.78%
Handling Instructions

PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.

For research use only. We do not sell to patients.

PIM-447 dihydrochloride Chemical Structure

PIM-447 dihydrochloride Chemical Structure

CAS No. : 1820565-69-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 418 In-stock
Estimated Time of Arrival: December 31
1 mg USD 135 In-stock
Estimated Time of Arrival: December 31
5 mg USD 370 In-stock
Estimated Time of Arrival: December 31
10 mg USD 630 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of PIM-447 dihydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE PIM-447 dihydrochloride

    PIM-447 dihydrochloride purchased from MCE. Usage Cited in: J Pathol. 2020 Jun 19.

    The alteration of MAPK/ERK pathway is validated by Western blotting with tumour lysates from the animal model, as illustrated by a downregulation of pERK1/2 in the PIM447 treatment group.
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    Description

    PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis[1][2].

    Clinical Trial
    Molecular Weight

    513.38

    Formula

    C₂₄H₂₅Cl₂F₃N₄O

    CAS No.

    1820565-69-2

    SMILES

    O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([[email protected]]4C[[email protected]@H](N)C[[email protected]@H](C)C4)C=CN=C3.Cl.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46.7 mg/mL (90.97 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9479 mL 9.7394 mL 19.4787 mL
    5 mM 0.3896 mL 1.9479 mL 3.8957 mL
    10 mM 0.1948 mL 0.9739 mL 1.9479 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.78%

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    Keywords:

    PIM-447LGH447PIM447PIM 447LGH 447LGH-447PimPim kinasesInhibitorinhibitorinhibit

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    Product Name:
    PIM-447 dihydrochloride
    Cat. No.:
    HY-19322B
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