1. JAK/STAT Signaling
  2. Pim
  3. (1S,3R,5R)-PIM447 dihydrochloride

(1S,3R,5R)-PIM447 dihydrochloride (Synonyms: (1S,3R,5R)-LGH447 dihydrochloride)

Cat. No.: HY-19322C Purity: 98.13%
Handling Instructions

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

For research use only. We do not sell to patients.

(1S,3R,5R)-PIM447 dihydrochloride Chemical Structure

(1S,3R,5R)-PIM447 dihydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 621 In-stock
Estimated Time of Arrival: December 31
1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Other Forms of (1S,3R,5R)-PIM447 dihydrochloride:

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Description

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

IC50 & Target

IC50: 0.095 μM (Pim1), 0.52 μM (Pim1), 0.369 μM (Pim1)

Molecular Weight

513.38

Formula

C₂₄H₂₅Cl₂F₃N₄O

SMILES

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([[email protected]@H]4C[[email protected]](N)C[[email protected]](C)C4)C=CN=C3.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (64.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9479 mL 9.7394 mL 19.4787 mL
5 mM 0.3896 mL 1.9479 mL 3.8957 mL
10 mM 0.1948 mL 0.9739 mL 1.9479 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (5.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (5.36 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(1S,3R,5R)-PIM447(1S,3R,5R)-LGH447PimPim kinasesInhibitorinhibitorinhibit

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Product Name:
(1S,3R,5R)-PIM447 dihydrochloride
Cat. No.:
HY-19322C
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