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Cat. No.: HY-101126R

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Nuvisertib (Standard)

Name: Nuvisertib (Standard)
Brand: MedChemExpress
SKU: HY-101126R
Price: 180.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: TP-3654 (Standard))

Nuvisertib (Standard) (TP-3654 (Standard)) is the analytical standard of Nuvisertib (HY-101126). This product is intended for research and analytical applications. Nuvisertib (TP-3654) is an orally active second-generation pan-PIM kinase inhibitor with K_i values of 5 nM, 239 nM, and 42 nM against PIM-1, PIM-2, and PIM-3, respectively. Nuvisertib inhibits JAK-independent inflammatory and survival signaling pathways, reduces the production of proinflammatory cytokines, restores apoptotic sensitivity, inhibits mTORC1, MYC, and TGF-β signaling pathways, and decreases the expression of fibrosis markers. Nuvisertib selectively impairs the transport function of ABCG2, resensitizes multidrug-resistant cancer cells to cytotoxic drugs, and overcomes JAK2 inhibitor resistance. Nuvisertib can be used in research related to myelofibrosis, renal cell carcinoma, multidrug-resistant cancer, advanced solid tumors, urothelial carcinoma, and prostate adenocarcinoma.

For research use only. We do not sell to patients.

Purity : 98%
CAS No.: 1361951-15-6
Formula: C₂₂H₂₅F₃N₄O
Molecular Weight:418.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nuvisertib (Standard) Chemical Structure

CAS No.: 1361951-15-6

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The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1361951-15-6
Molecular Weight 418.46
Formula C₂₂H₂₅F₃N₄O
SMILES

OC(C)(C)[C@H]1CC[C@H](NC2=NN3C(C=C2)=NC=C3C4=CC=CC(C(F)(F)F)=C4)CC1
Synonyms

TP-3654 (Standard)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Abruzzese E, et al. The Path Forward in MF: Small Molecules in the Limelight. Cancers (Basel). 2026 Apr 25;18(9):1370.

[2]. El Chaer F, et al. Nuvisertib (TP-3654), an investigational selective PIM1 kinase inhibitor, showed durable clinical response and sustained hematological improvement in relapsed/refractory myelofibrosis patients. Blood. 2024;144(Suppl 1):655.

[3]. Mascarenhas J, et al. Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis. Blood. 2025;146(Suppl 1):482. Abstract 634A.

[4]. Meza KS, et al. Abstract 3174: Nuvisertib (TP‑3654) and Dordaviprone (ONC201) synergize to reduce renal cell carcinoma cell viability. Cancer Res. 2026;86(7_Supplement):3174.

[5]. Dutta A, et al. Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models. Leukemia. 2022 Mar;36(3):746-759.

[6]. Wu CP, et al. The Second-Generation PIM Kinase Inhibitor TP-3654 Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs. International journal of molecular sciences. 2021 Aug 30;22(17):9440.

[7]. Foulks JM, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia. 2014 May;16(5):403-12. [Content Brief]

[8]. Nath D, et al. The PIM Kinase Inhibitor TP‑3654 in Combination with Ruxolitinib Exhibits Marked Improvement of Myelofibrosis in Murine Models. Blood. 2018;132(Suppl 1):54. Abstract 635.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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