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Cat. No.: HY-150731

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Pim-1 kinase inhibitor 3

Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC₅₀ of 35.13 nM.

For research use only. We do not sell to patients.

CAS No.: 2801695-39-4
Formula: C₂₀H₂₅N₃O₂
Molecular Weight:339.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Pim-1 kinase inhibitor 3 Chemical Structure

CAS No.: 2801695-39-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC₅₀ of 35.13 nM^[1].

IC₅₀ & Target

PIM1

35.13 nM (IC₅₀)

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	8.154 μM Compound: H5	Antiproliferative activity against human MDA-MD-231 cells measured by cell viability assay Antiproliferative activity against human MDA-MD-231 cells measured by cell viability assay	[PMID: 35779826]

In Vitro

Pim-1 kinase inhibitor 3 (Compound H5) (0-100 μM, 48 h) inhibits MDA-MD-231 cell proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MD-231
Concentration:

0-100 μM
Incubation Time:

48 h
Result:

Inhibited cell proliferation with an IC₅₀ of 8.154 μM.

Chemical Information

CAS No. 2801695-39-4
Molecular Weight 339.43
Formula C₂₀H₂₅N₃O₂
SMILES

C12=CC3=C(C=C2)OC4=C(C=CN=C4)N3CCCCCNCCCCO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu J, et al. Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors. Bioorg Med Chem Lett. 2022 Sep 15;72:128874. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Pim-1 kinase inhibitor 3

All Pim Isoforms