1. JAK/STAT Signaling
  2. Pim
  3. (Z)-SMI-4a

(Z)-SMI-4a 

Cat. No.: HY-16576A
Handling Instructions

(Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 µM. (Z)-SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity.

For research use only. We do not sell to patients.

(Z)-SMI-4a Chemical Structure

(Z)-SMI-4a Chemical Structure

CAS No. : 438190-29-5

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Description

(Z)-SMI-4a is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 µM. (Z)-SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. (Z)-SMI-4a has anticancer activity[1].

IC50 & Target[1]

PIM1

24 μM (IC50)

PIM1

0.6 μM (Ki)

PIM2

100 μM (IC50)

In Vitro

(Z)-SMI-4a (0.5 µM; 1 hour; HEK-293T cells) treatment attenuates the autophosphorylation of tagged Pim-1 in intact cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK-293T cells
Concentration: 0.5 µM
Incubation Time: 1 hour
Result: Caused a dose-dependent reduction in Pim-1-induced 4E-BP1 phosphorylation, with an IC50 of approximately 125 nM.
Molecular Weight

273.23

Formula

C₁₁H₆F₃NO₂S

CAS No.

438190-29-5

SMILES

O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(Z)-SMI-4aPimPim kinasesPim-1Pim-24E-BP1autophosphorylationcell-permeableanticancerInhibitorinhibitorinhibit

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(Z)-SMI-4a
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