438190-29-5
438190-29-5
Chemical Structure
SMI-4a
Synonym(s): TCS-PIM-1-4a
- CAS No.: 438190-29-5
- Formula:C11H6F3NO2S
- Molecular Weight:273.23
IUPAC Name: (Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione
InChIKey: NGJLOFCOEOHFKQ-YVMONPNESA-N
SMILES: O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2
Biological Activity: SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SMI-4a | 99.85% | SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-W288798DCAF11 ligand 2 -
Similarity Score 0.71
HY-W412264Pim-1/2 kinase inhibitor 1 -
Similarity Score 0.70
HY-133133IIIM-1270 -
Similarity Score 0.70
HY-131048Antimicrobial agent-33 -
Similarity Score 0.70
HY-131051Antimicrobial agent-41 -
Similarity Score 0.69
HY-118521AS-041164 -
Similarity Score 0.69
HY-13531AS-604850 -
Similarity Score 0.68
HY-101947RSMI-16a (Standard) -
Similarity Score 0.68
HY-131728GPR35 agonist 3 -
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