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  3. AS-041164

AS-041164 

Cat. No.: HY-118521 Purity: 99.32%
Handling Instructions

AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects.

For research use only. We do not sell to patients.

AS-041164 Chemical Structure

AS-041164 Chemical Structure

CAS No. : 6318-41-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].

IC50 & Target[1]

PI3Kγ

70 nM (IC50)

PI3Kα

240 nM (IC50)

PI3Kβ

1.4 μM (IC50)

PI3Kδ

1.7 μM (IC50)

In Vivo

AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema[1].
AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (100-150 g) injected with carrageenan[1]
Dosage: 10 mg/kg, 30 mg/kg, 100 mg/kg
Administration: Oral administration; once
Result: Induced a significant reduction of paw thickness.
Molecular Weight

249.24

Formula

C₁₁H₇NO₄S

CAS No.
SMILES

O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (501.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0122 mL 20.0610 mL 40.1220 mL
5 mM 0.8024 mL 4.0122 mL 8.0244 mL
10 mM 0.4012 mL 2.0061 mL 4.0122 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.47 mg/mL (5.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.32%

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Keywords:

AS-041164AS041164AS 041164PI3KPhosphoinositide 3-kinasePI3Kγanti-inflammatoryneutrophilrecruitmentRANTESInhibitorinhibitorinhibit

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Product Name:
AS-041164
Cat. No.:
HY-118521
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