6318-41-8
6318-41-8
Chemical Structure
AS-041164
- CAS No.: 6318-41-8
- Formula:C11H7NO4S
- Molecular Weight:249.24
IUPAC Name: (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
InChIKey: SDGWAUUPHUBJNQ-WTKPLQERSA-N
SMILES: O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2
Biological Activity: AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AS-041164 | 99.02% | AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.81
HY-13531AS-604850 -
Similarity Score 0.76
HY-131051Antimicrobial agent-41 -
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HY-W838814ERK1/2 inhibitor 12 -
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HY-W412264Pim-1/2 kinase inhibitor 1 -
Similarity Score 0.70
HY-114664KNK423 -
Similarity Score 0.70
HY-101947RSMI-16a (Standard) -
Similarity Score 0.69
HY-16576ASMI-4a -
Similarity Score 0.69
HY-131728GPR35 agonist 3 -
Similarity Score 0.69
HY-10109AS-605240 -
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