Pim-1/2 kinase inhibitor 1
Based on 1 Customer Validation
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer.
For research use only. We do not sell to patients.
- Purity : 99.78%
- CAS No.: 6320-51-0
- Formula: C11H9NO3S
- Molecular Weight:235.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
172 μM
Compound: 19a
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 34826680] |
| HepG2 | EC50 |
200 μM
Compound: 19a
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 34826680] |
| PC-12 | IC50 |
23 μM
Compound: 11b
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Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay
Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay
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[PMID: 15109648] |
| PC-3 | IC50 |
11 μM
Compound: 10a
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Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay
Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay
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[PMID: 19072652] |
In Vitro
Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:varying concentrations
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Incubation Time:48 h
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Result:Inhibited PC3 cells with an IC
Chemical Information
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CAS No. 6320-51-0
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Appearance Solid
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Molecular Weight 235.26
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Formula C11H9NO3S
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Color Light yellow to yellow
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SMILES
O=C(NC1=O)SC1=CC2=CC=C(OC)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 250 mg/mL (1062.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2506 mL | 21.2531 mL | 42.5062 mL | 106.2654 mL |
| 5 mM | 0.8501 mL | 4.2506 mL | 8.5012 mL | 21.2531 mL | |
| 10 mM | 0.4251 mL | 2.1253 mL | 4.2506 mL | 10.6265 mL | |
| 15 mM | 0.2834 mL | 1.4169 mL | 2.8337 mL | 7.0844 mL | |
| 20 mM | 0.2125 mL | 1.0627 mL | 2.1253 mL | 5.3133 mL | |
| 25 mM | 0.1700 mL | 0.8501 mL | 1.7002 mL | 4.2506 mL | |
| 30 mM | 0.1417 mL | 0.7084 mL | 1.4169 mL | 3.5422 mL | |
| 40 mM | 0.1063 mL | 0.5313 mL | 1.0627 mL | 2.6566 mL | |
| 50 mM | 0.0850 mL | 0.4251 mL | 0.8501 mL | 2.1253 mL | |
| 60 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.7711 mL | |
| 80 mM | 0.0531 mL | 0.2657 mL | 0.5313 mL | 1.3283 mL | |
| 100 mM | 0.0425 mL | 0.2125 mL | 0.4251 mL | 1.0627 mL |
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