1. JAK/STAT Signaling
  2. Pim
  3. Quercetagetin

Quercetagetin (Synonyms: 6-Hydroxyquercetin)

Cat. No.: HY-N4149
Handling Instructions

Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu (C. unshiu) peel. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.

For research use only. We do not sell to patients.

Quercetagetin Chemical Structure

Quercetagetin Chemical Structure

CAS No. : 90-18-6

Size Price Stock
5 mg USD 260 Get quote
10 mg USD 390 Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu (C. unshiu) peel[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.

IC50 & Target[2]

PIM1

0.34 μM (IC50)

PIM2

3.45 μM (IC50)

RSK2

2.82 μM (IC50)

PKA

21.2 μM (IC50)

In Vitro

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC50s of 3.45, 21.2, and 2.82 µM, respectively[2].
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM[2].

Cell Viability Assay[2]

Cell Line: RWPE2 prostate cancer cells
Concentration: 0.1, 1, 10, and 100 μM
Incubation Time: 72 hours
Result: Inhibited growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM.
In Vivo

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3].

Animal Model: SKH-1 hairless mice model[3]
Dosage: 4 or 20 nmol
Administration: Topical application; 28 weeks
Result: Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.
Molecular Weight

318.24

Formula

C₁₅H₁₀O₈

CAS No.

90-18-6

SMILES

O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=C(O)C(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Quercetagetin
Cat. No.:
HY-N4149
Quantity: