1. JAK/STAT Signaling
  2. Pim
  3. Quercetagetin

Quercetagetin (Synonyms: 6-Hydroxyquercetin)

Cat. No.: HY-N4149 Purity: 99.24%
Handling Instructions

Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu (C. unshiu) peel. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.

For research use only. We do not sell to patients.

Quercetagetin Chemical Structure

Quercetagetin Chemical Structure

CAS No. : 90-18-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 286 In-stock
Estimated Time of Arrival: December 31
5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 390 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 3 publication(s) in Google Scholar

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Description

Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu (C. unshiu) peel[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.

IC50 & Target[2]

PIM1

0.34 μM (IC50)

PIM2

3.45 μM (IC50)

RSK2

2.82 μM (IC50)

PKA

21.2 μM (IC50)

In Vitro

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC50s of 3.45, 21.2, and 2.82 µM, respectively[2].
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: RWPE2 prostate cancer cells
Concentration: 0.1, 1, 10, and 100 μM
Incubation Time: 72 hours
Result: Inhibited growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM.
In Vivo

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SKH-1 hairless mice model[3]
Dosage: 4 or 20 nmol
Administration: Topical application; 28 weeks
Result: Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.
Molecular Weight

318.24

Formula

C₁₅H₁₀O₈

CAS No.

90-18-6

SMILES

O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=C(O)C(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1423 mL 15.7114 mL 31.4228 mL
5 mM 0.6285 mL 3.1423 mL 6.2846 mL
10 mM 0.3142 mL 1.5711 mL 3.1423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Quercetagetin6-HydroxyquercetinPimPim kinasesInhibitorinhibitorinhibit

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Quercetagetin
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