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(-)-Epigallocatechin Gallate

(Synonyms: EGCG; Epigallocatechol Gallate)
65 Cited Publications
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Based on 65 publication(s) in Google Scholar

(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.

For research use only. We do not sell to patients.

  • Purity: 99.58%
  • CAS No.: 989-51-5
  • Formula: C22H18O11
  • Molecular Weight:458.37
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • (-)-Epigallocatechin Gallate Chemical Structure
    (-)-Epigallocatechin Gallate Chemical Structure
  • Experimental Validation Results for (-)-Epigallocatechin Gallate
  • Experimental Validation Results for (-)-Epigallocatechin Gallate
  • Experimental Validation Results for (-)-Epigallocatechin Gallate
  • Experimental Validation Results for (-)-Epigallocatechin Gallate
  • Experimental Validation Results for (-)-Epigallocatechin Gallate
  • Experimental Validation Results for (-)-Epigallocatechin Gallate
CAS No.: 989-51-5
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  • (-)-Epigallocatechin Gallate Chemical Structure
    (-)-Epigallocatechin Gallate Chemical Structure
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    (-)-Epigallocatechin Gallate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

    Customer Validation
     (A) Schematic diagram of the synthesis steps of PN@Col nanoparticles(61 mg (-)-Epigallocatechin Gallate (EGCG), 10 mg Glycine and 2 mg Colivelin);(B) Morphological features of PN (top) and PN@Col (bottom) observed using TEM (scale bar: 100 nm/200 nm);(C) Morphology of PN (top) and PN@Col (bottom) observed using SEM (scale bar: 5 μm/1 μm);

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    (-)-Epigallocatechin Gallate purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2024 Aug;16(8):1817-1839. [Abstract]

    Customer Validation
     The ZIKV (2 × 106 PFU) samples were incubated with the indicated compounds (HC-070 (2.5 and 5 μM), KN-93 (5 and 10 μM), or (-)-Epigallocatechin Gallate (EGCG, 25 μM) or an equal volume of vehicle at 4 °C, 25 °C, and 37 °C for a duration of 1 h. Subsequently, the infectious viral particles in each sample were quantified using the PFU assay (n = 3 biological replicates). EGCG was employed as the positive control. Neither HC-070 nor KN-93 exhibited any impact on the infectivity of ZIKV particles in vitro.

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    (-)-Epigallocatechin Gallate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Jul 29;14(7):481. [Abstract]

    Customer Validation
     Growth curves of 2BS cells treated with DMSO (control), R162 (2 nM) or (-)-Epigallocatechin Gallate (EGCG, 10 nM; 2-6 days) were determined by CCK-8 assay.

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    (-)-Epigallocatechin Gallate purchased from MedChemExpress. Usage Cited in: Br J Cancer. 2021 Jan;124(2):425-436. [Abstract]

    Customer Validation
     The IC50 values of capecitabine and oxaliplatin combined with or without (-)-Epigallocatechin Gallate (EGCG) treatment (25 μM, 48 h) were examined by CCK-8 assay. The results showed that pharmacological inhibition of G3BP1 with the specific inhibitor EGCG greatly reduced the IC50 of capecitabine and oxaliplatin.

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    (-)-Epigallocatechin Gallate purchased from MedChemExpress. Usage Cited in: Aging Cell. 2020 Oct;19(10):e13217. [Abstract]

    Customer Validation
     540-day-old mice received intraperitoneal (i.p.) injections of (-)-Epigallocatechin Gallate (EGCG; 50 mg/kg) for 3 consecutive days, followed by a 4-day break. This cycle was repeated for a total of 4 times. Following EGCG treatment, testes from different ages of mice were subjected to immunoblotting analysis.

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    (-)-Epigallocatechin Gallate purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2017 Nov;14(5):6314-6320. [Abstract]

    Customer Validation
     Effects of (-)-Epigallocatechin Gallate (EGCG) on the levels of SHP-1 and p-p38α protein expression in NB4 cells. NB4 cells were treated with 10, 20 and 30 µM EGCG for 24 h. Western blot analysis was used to detect SHP-1, p38α and p-p38α protein expression. EGCG, epigallocatechin-3-gallate; SHP-1, Src homology region 2 domain-containing phosphatase-1; p38α, p38α mitogen activated protein kinase; p-, phosphorylated.

  • (-)-Epigallocatechin Gallate