2. Academic Validation
  3. Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors

  • J Med Chem. 2014 Nov 13;57(21):8718-28. doi: 10.1021/jm500823a.
Rohit Bhat 1,  Sreedhar R Tummalapalli,  David P Rotella
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Sokol Institute for Pharmaceutical Life Sciences, Montclair State University , Montclair, New Jersey 07043, United States.
PMID: 25141341 DOI: 10.1021/jm500823a
Abstract

The discovery and clinical development of heat shock protein 90 (HSP90) inhibitors continue to progress. A number of HSP90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.

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