2. Academic Validation
  3. Polyphenol-assisted facile assembly of bioactive nanoparticles for targeted therapy of heart diseases

Polyphenol-assisted facile assembly of bioactive nanoparticles for targeted therapy of heart diseases

  • Biomaterials. 2021 Aug:275:120952. doi: 10.1016/j.biomaterials.2021.120952.
Yuantong Qi 1,  Jingru Li 2,  Qiang Nie 1,  Mingjie Gao 1,  Qinghua Yang 1,  Zimeng Li 1,  Qi Li 2,  Songling Han 3,  Jun Ding 4,  Yongqin Li 5,  Jianxiang Zhang 6
Affiliations

Affiliations

  • 1 Department of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • 2 Department of Biomedical Engineering and Medical Imaging, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • 3 State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • 4 Department of Ultrasound, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • 5 Department of Biomedical Engineering and Medical Imaging, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address: [email protected].
  • 6 Department of Pharmaceutics, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing 400038, China; State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address: [email protected].
PMID: 34147720 DOI: 10.1016/j.biomaterials.2021.120952
Abstract

It remains a great challenge for targeted therapy of heart diseases. To achieve desirable heart targeting, we developed a polyphenol-assisted nanoprecipitation/self-assembly approach for facile engineering of functional nanoparticles. Three different Materials were employed as representative carriers, while gallic acid, catechin, epigallocatechin gallate, and tannic acid (TA) served as typical Polyphenols with varied numbers of phenolic hydroxyl groups. By optimizing different parameters, such as polyphenol types and the weight ratio of carrier Materials and Polyphenols, well-defined nanoparticles with excellent physicochemical properties can be easily prepared. Regardless of various carrier Materials, TA-derived nanoparticles showed potent reactive oxygen species-scavenging activity, especially nanoparticles produced from a cyclodextrin-derived bioactive material (TPCD). By internalization into cardiomyocytes, TPCD/TA nanoparticles (defined as TPTN) effectively protected cells from hypoxic-ischemic injury. After intravenous injection, TPTN considerably accumulated in the injured heart in two murine models of ventricular fibrillation cardiac arrest in rats and myocardial hypertrophy in mice. Correspondingly, intravenously delivered TPTN afforded excellent therapeutic effects in both heart diseases. Preliminary experiments also revealed good safety of TPTN. These results substantiated that TPTN is a promising nanotherapy for targeted treatment of heart diseases, while polyphenol-assisted self-assembly is a facile but robust strategy to develop heart-targeting delivery systems.

Keywords

Heart diseases; Nanoparticles; Polyphenols; Self-assembly; Targeted therapy.

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