(-)-Epigallocatechin
Based on 5 publication(s) in Google Scholar
(-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 970-74-1
- Formula: C15H14O7
- Molecular Weight:306.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0002
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HY-13653
(-)-Epigallocatechin Gallate
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HY-N0001
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HY-N0162
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HY-N1201
Apigenin
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HY-N0225R
(-)-Epigallocatechin (Standard)
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HY-13653R
(-)-Epigallocatechin Gallate (Standard)
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HY-N0522
(-)-Gallocatechin gallate
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HY-N0521
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HY-N0796
Procyanidin B2
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HY-N0356
(-)-Catechin gallate
Publications Citing Use of MedChemExpress (MCE) (-)-Epigallocatechin
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Customer Validation & Images
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IF
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Bio/Physico-chemical Assay
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
>100 μM
Compound: 14
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Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction
Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction
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[PMID: 27623545] |
| H9 | IC50 |
1.8 μg/mL
Compound: 7
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Inhibition of uninfected H9 lymphocytic cell growth
Inhibition of uninfected H9 lymphocytic cell growth
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10.1016/0960-894X(96)00095-9 |
| HUVEC | IC50 |
8 μM
Compound: 42
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Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells
Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells
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10.1007/s00044-012-0353-y |
| MT4 | CC50 |
16.1 μg/mL
Compound: 13
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Cytotoxicity against human MT4 cells by MTT assay
Cytotoxicity against human MT4 cells by MTT assay
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[PMID: 10425115] |
| MT4 | IC50 |
>16.1 μg/mL
Compound: 13
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Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
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[PMID: 10425115] |
(-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that (-)-Epigallocatechin prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and (-)-Epigallocatechin (EGC) specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. (-)-Epigallocatechin (EGC) exhibits a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. (-)-Epigallocatechin induces the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, (-)-Epigallocatechin induces significant down-regulation of E. faecalis virulence genes [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 970-74-1
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Appearance Solid
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Molecular Weight 306.27
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Formula C15H14O7
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Color White to off-white
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SMILES
O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1
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Synonyms
Epigallocatechin; L-Epigallocatechin
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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J Agric Food Chem
High-Pressure and Thermal Pasteurization Applied to Smoothies Enhances (Poly)Phenol Bioaccessibility along the Gastrointestinal Tract. [Abstract]2025 Jun 25;73(25):15561-15578. PMID: 40497562 -
Food Funct
Polyphenol-rich extract from Torreya grandis peel attenuates lipopolysaccharide-induced inflammation in RAW264.7 macrophages via inhibition of the TLR4/NF-κB pathway. [Abstract]2025 Sep 26. PMID: 41002170 -
Plants
Metabolites of Prickly Rose: Chemodiversity and Digestive-Enzyme-Inhibiting Potential of Rosa acicularis and the Main Ellagitannin Rugosin D. [Abstract]2021 Nov 20;10(11):2525. PMID: 34834888 -
Pathogens
2026 Mar 20;15(3):334. PMID: 41901787
(-)-Epigallocatechin purchased from MedChemExpress. Usage Cited in: Pathogens. 2026 Mar 20;15(3):334. [Abstract]
Immunofluorescence analysis presenting that EGC ((-)-Epigallocatechin) (5-20 μM) exerts a slight inhibitory effect on the expression of ZIKV capsid protein (red) in A549 cells. Nuclei were counterstained in blue with DAPI. Original magnification was 200×, and the scale bar represented 50 μm. The infection rate was quantified as the ratio of ZIKV-positive cells to the total number of DAPI-positive cells.
(-)-Epigallocatechin purchased from MedChemExpress. Usage Cited in: Pathogens. 2026 Mar 20;15(3):334. [Abstract]
(-)-Epigallocatechin (EGC) (40 μM; 10-60 days). The hemolysis rate test showed that GTE mildly decreases the hemolysis rate of RBCs during storage.
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvent & Solubility
DMSO : 66.67 mg/mL (217.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang N, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26 [Content Brief]
[2]. Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46. [Content Brief]
[3]. Lee P, et al. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015 Mar;60(3):393-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2651 mL | 16.3255 mL | 32.6509 mL | 81.6273 mL |
| 5 mM | 0.6530 mL | 3.2651 mL | 6.5302 mL | 16.3255 mL | |
| 10 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 15 mM | 0.2177 mL | 1.0884 mL | 2.1767 mL | 5.4418 mL | |
| 20 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 25 mM | 0.1306 mL | 0.6530 mL | 1.3060 mL | 3.2651 mL | |
| 30 mM | 0.1088 mL | 0.5442 mL | 1.0884 mL | 2.7209 mL | |
| 40 mM | 0.0816 mL | 0.4081 mL | 0.8163 mL | 2.0407 mL | |
| 50 mM | 0.0653 mL | 0.3265 mL | 0.6530 mL | 1.6325 mL | |
| 60 mM | 0.0544 mL | 0.2721 mL | 0.5442 mL | 1.3605 mL | |
| 80 mM | 0.0408 mL | 0.2041 mL | 0.4081 mL | 1.0203 mL | |
| 100 mM | 0.0327 mL | 0.1633 mL | 0.3265 mL | 0.8163 mL |
(-)-Epigallocatechin Related Classifications
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