(-)-Epigallocatechin (Synonyms: Epigallocatechin; L-Epigallocatechin)

Name: (-)-Epigallocatechin
Brand: MedChemExpress
SKU: HY-N0225
Rating: 5.0 (5 reviews)

Cat. No.: HY-N0225 Pureza: 99.66%: Ficha de datos
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(-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.

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No. CAS : 970-74-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
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Revisión del cliente

Based on 5 publication(s) in Google Scholar

Other Forms of (-)-Epigallocatechin:

(-)-Epigallocatechin Gallate In-stock
(-)-Gallocatechin In-stock
(+)-Gallocatechin In-stock
(-)-Epigallocatechin (Standard) In-stock

5 Publications Citing Use of MCE (-)-Epigallocatechin

Bio/Physico-chemical Assay

: (-)-Epigallocatechin purchased from MedChemExpress. Usage Cited in: Pathogens. 2026 Mar 20;15(3):334. [Abstract]; Immunofluorescence analysis presenting that EGC ((-)-Epigallocatechin) (5-20 μM) exerts a slight inhibitory effect on the expression of ZIKV capsid protein (red) in A549 cells. Nuclei were counterstained in blue with DAPI. Original magnification was 200×, and the scale bar represented 50 μm. The infection rate was quantified as the ratio of ZIKV-positive cells to the total number of DAPI-positive cells.

: (-)-Epigallocatechin purchased from MedChemExpress. Usage Cited in: Pathogens. 2026 Mar 20;15(3):334. [Abstract]; (-)-Epigallocatechin (EGC) (40 μM; 10-60 days). The hemolysis rate test showed that GTE mildly decreases the hemolysis rate of RBCs during storage.

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•Related Screening Libraries:

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•Related Proteins:

Ver todos los productos específicos de isoformas MMP:

Ver todas las isoformas

MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

(-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	>100 μM Compound: 14	Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction	[PMID: 27623545]
H9	IC₅₀	1.8 μg/mL Compound: 7	Inhibition of uninfected H9 lymphocytic cell growth Inhibition of uninfected H9 lymphocytic cell growth	10.1016/0960-894X(96)00095-9
HUVEC	IC₅₀	8 μM Compound: 42	Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells	10.1007/s00044-012-0353-y
MT4	CC₅₀	16.1 μg/mL Compound: 13	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 10425115]
MT4	IC₅₀	>16.1 μg/mL Compound: 13	Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 10425115]

In Vitro

(-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that (-)-Epigallocatechin prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and (-)-Epigallocatechin (EGC) specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. (-)-Epigallocatechin (EGC) exhibits a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. (-)-Epigallocatechin induces the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, (-)-Epigallocatechin induces significant down-regulation of E. faecalis virulence genes [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

306.27

Fòrmula

C₁₅H₁₄O₇

No. CAS

970-74-1

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1

Structure Classification

Initial Source

Microorganisms

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 66.67 mg/mL (217.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2651 mL	16.3255 mL	32.6509 mL
5 mM	0.6530 mL	3.2651 mL	6.5302 mL
10 mM	0.3265 mL	1.6325 mL	3.2651 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.66%

Select Batch:

Ficha de datos (276 KB) SDS (396 KB)

COA (250 KB) LCMS (86 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang N, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26 [Content Brief]

[2]. Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46. [Content Brief]

[3]. Lee P, et al. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015 Mar;60(3):393-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2651 mL	16.3255 mL	32.6509 mL	81.6273 mL
	5 mM	0.6530 mL	3.2651 mL	6.5302 mL	16.3255 mL
	10 mM	0.3265 mL	1.6325 mL	3.2651 mL	8.1627 mL
	15 mM	0.2177 mL	1.0884 mL	2.1767 mL	5.4418 mL
	20 mM	0.1633 mL	0.8163 mL	1.6325 mL	4.0814 mL
	25 mM	0.1306 mL	0.6530 mL	1.3060 mL	3.2651 mL
	30 mM	0.1088 mL	0.5442 mL	1.0884 mL	2.7209 mL
	40 mM	0.0816 mL	0.4081 mL	0.8163 mL	2.0407 mL
	50 mM	0.0653 mL	0.3265 mL	0.6530 mL	1.6325 mL
	60 mM	0.0544 mL	0.2721 mL	0.5442 mL	1.3605 mL
	80 mM	0.0408 mL	0.2041 mL	0.4081 mL	1.0203 mL
	100 mM	0.0327 mL	0.1633 mL	0.3265 mL	0.8163 mL

(-)-Epigallocatechin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Epigallocatechin970-74-1Epigallocatechin L-EpigallocatechinMMPAutophagyMatrix metalloproteinasesInhibitorinhibitorinhibit

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(-)-Epigallocatechin (Synonyms: Epigallocatechin; L-Epigallocatechin)

Revisión del cliente

Other Forms of (-)-Epigallocatechin:

(-)-Epigallocatechin Related Antibodies

5 Publications Citing Use of MCE (-)-Epigallocatechin

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas MMP:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

(-)-Epigallocatechin Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

(-)-Epigallocatechin Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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