2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) Interleukin Related
  4. IIIM-1270

IIIM-1270is a NLRP3 inflammasome inhibitor. IIIM-1270 inhibits IL-1β release in mouse macrophages (J774A.1 cells) (IC50 = 3.5 μM) and significantly reduced the protein expression level of mature IL-1β. IIIM-1270 can be used for the study of inflammation.

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IIIM-1270

IIIM-1270 Chemical Structure

CAS No. : 4818-19-3

Size Price Stock Quantity
Powder + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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5 mg In-stock
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Based on 1 publication(s) in Google Scholar

IIIM-1270 Related Antibodies

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Description

IIIM-1270is a NLRP3 inflammasome inhibitor. IIIM-1270 inhibits IL-1β release in mouse macrophages (J774A.1 cells) (IC50 = 3.5 μM) and significantly reduced the protein expression level of mature IL-1β. IIIM-1270 can be used for the study of inflammation[1].

Molecular Weight

233.29

Formula

C12H11NO2S
CAS No.
Appearance

Powder

Color

off-white

SMILES

CC1=CC=C(/C=C2SC(NC/2=O)=O)C(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (107.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2865 mL 21.4326 mL 42.8651 mL
5 mM 0.8573 mL 4.2865 mL 8.5730 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2865 mL 21.4326 mL 42.8651 mL 107.1628 mL
5 mM 0.8573 mL 4.2865 mL 8.5730 mL 21.4326 mL
10 mM 0.4287 mL 2.1433 mL 4.2865 mL 10.7163 mL
15 mM 0.2858 mL 1.4288 mL 2.8577 mL 7.1442 mL
20 mM 0.2143 mL 1.0716 mL 2.1433 mL 5.3581 mL
25 mM 0.1715 mL 0.8573 mL 1.7146 mL 4.2865 mL
30 mM 0.1429 mL 0.7144 mL 1.4288 mL 3.5721 mL
40 mM 0.1072 mL 0.5358 mL 1.0716 mL 2.6791 mL
50 mM 0.0857 mL 0.4287 mL 0.8573 mL 2.1433 mL
60 mM 0.0714 mL 0.3572 mL 0.7144 mL 1.7860 mL
80 mM 0.0536 mL 0.2679 mL 0.5358 mL 1.3395 mL
100 mM 0.0429 mL 0.2143 mL 0.4287 mL 1.0716 mL
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IIIM-1270 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IIIM-12704818-19-3IIIM1270IIIM 1270NOD-like Receptor (NLR)Interleukin RelatedILNLRP3 inflammasomeinflammationInhibitorinhibitorinhibit

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