Ageladine A dihydrochloride
Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase (MMP) isolated from the marine sponge Agelas nakamurai, possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC50 values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values.
For research use only. We do not sell to patients.
- CAS No.: 2757574-06-2
- Formula: C10H9Br2Cl2N5
- Molecular Weight:429.93
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
MMP-1 2.79 μM (IC50) |
MMP-2 4.65 μM (IC50) |
MMP-8 907.12 nM (IC50) |
MMP-9 1.83 μM (IC50) |
MMP-12 767.57 nM (IC50) |
MMP13 1.09 μM (IC50) |
Chemical Information
-
CAS No. 2757574-06-2
-
Molecular Weight 429.93
-
Formula C10H9Br2Cl2N5
-
SMILES
BrC1=C(Br)NC(C2=NC=CC3=C2N=C(N)N3)=C1.Cl.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Fujita M, et al. Ageladine A: An Antiangiogenic Matrixmetalloproteinase Inhibitor from the Marine Sponge Agelas N Akamurai[J]. Journal of the American Chemical Society, 2003, 125(51): 15700-15701. [Content Brief]
[2]. Bickmeyer U, et al. Ageladine A, a pyrrole–imidazole alkaloid from marine sponges, is a pH sensitive membrane permeable dye[J]. Biochemical and biophysical research communications, 2008, 373(3): 419-422. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ageladine A dihydrochloride Related Classifications
HY-113621B Related Classifications
Powered by Bioz