Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai

  • J Am Chem Soc. 2003 Dec 24;125(51):15700-1. doi: 10.1021/ja038025w.
Masaki Fujita  1 ,  Yoichi Nakao ,  Shigeki Matsunaga ,  Motoharu Seiki ,  Yoshifumi Itoh ,  Jun Yamashita ,  Rob W M Van Soest ,  Nobuhiro Fusetani
Affiliations
  • 1. Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
PMID: 14677933 DOI: 10.1021/ja038025w
Abstract

A novel MMP Inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine Sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.

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