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Cat. No.: HY-184811

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PIM-IN-6

PIM-IN-6 is an inhibitor of PIM1 and PIM2, with an IC₅₀ of 254 nM against PIM1 and an IC₅₀ of 1.78 μM against PIM2. PIM-IN-6 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 2698319-19-4
Formula: C₁₅H₁₈ClFN₄O
Molecular Weight:324.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIM-IN-6 Chemical Structure

CAS No.: 2698319-19-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

PIM1

254 nM (IC₅₀)

PIM2

1.78 μM (IC₅₀)

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KG-1	EC₅₀	7230 nM Compound: 25	Cytotoxicity against human KG-1 cells assessed as reduction in cell viability Cytotoxicity against human KG-1 cells assessed as reduction in cell viability	[PMID: 33096160]

In Vitro

PIM-IN-6 inhibits purified PIM1 and PIM2 kinases with IC₅₀ values of 254 nM and 1780 nM, respectively^[1].
PIM-IN-6 reduces KG1 human acute myeloid leukemia cell viability with an EC₅₀ of 7230 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2698319-19-4
Molecular Weight 324.78
Formula C₁₅H₁₈ClFN₄O
SMILES

C[C@H]([C@]1(CCNC1)F)N2C3=NC(C(N)=O)=CC(Cl)=C3C(C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Barberis C, et al. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorganic & medicinal chemistry letters. 2020 Dec 01;30(23):127625. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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