PIM-IN-6
PIM-IN-6 is an inhibitor of PIM1 and PIM2, with an IC50 of 254 nM against PIM1 and an IC50 of 1.78 μM against PIM2. PIM-IN-6 can be used for the research of acute myeloid leukemia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2698319-19-4
- Formule: C15H18ClFN4O
- Masse moléculaire:324.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
PIM1 254 nM (IC50) |
PIM2 1.78 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KG-1 | EC50 |
7230 nM
Compound: 25
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Cytotoxicity against human KG-1 cells assessed as reduction in cell viability
Cytotoxicity against human KG-1 cells assessed as reduction in cell viability
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[PMID: 33096160] |
In Vitro
PIM-IN-6 inhibits purified PIM1 and PIM2 kinases with IC50 values of 254 nM and 1780 nM, respectively[1].
PIM-IN-6 reduces KG1 human acute myeloid leukemia cell viability with an EC50 of 7230 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2698319-19-4
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Masse moléculaire 324.78
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Formule C15H18ClFN4O
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SMILES
C[C@H]([C@]1(CCNC1)F)N2C3=NC(C(N)=O)=CC(Cl)=C3C(C)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PIM-IN-6 Related Classifications
HY-184811 Related Classifications
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