2. JAK/STAT Signaling
  3. Pim
  4. PIM1-IN-2

PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds.

For research use only. We do not sell to patients.

PIM1-IN-2 Chemical Structure

PIM1-IN-2 Chemical Structure

CAS No. : 477845-12-8

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Based on 1 publication(s) in Google Scholar

PIM1-IN-2 Related Antibodies

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Description

PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].

IC50 & Target

PIM1

91 nM (Ki)

Molecular Weight

322.75

Formula

C17H11ClN4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=NC=CC(C2=CC3=C(C4=CC=C(Cl)C=C4)ON=C3C=C2)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (61.97 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0984 mL 15.4919 mL 30.9837 mL
5 mM 0.6197 mL 3.0984 mL 6.1967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0984 mL 15.4919 mL 30.9837 mL 77.4593 mL
5 mM 0.6197 mL 3.0984 mL 6.1967 mL 15.4919 mL
10 mM 0.3098 mL 1.5492 mL 3.0984 mL 7.7459 mL
15 mM 0.2066 mL 1.0328 mL 2.0656 mL 5.1640 mL
20 mM 0.1549 mL 0.7746 mL 1.5492 mL 3.8730 mL
25 mM 0.1239 mL 0.6197 mL 1.2393 mL 3.0984 mL
30 mM 0.1033 mL 0.5164 mL 1.0328 mL 2.5820 mL
40 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.9365 mL
50 mM 0.0620 mL 0.3098 mL 0.6197 mL 1.5492 mL
60 mM 0.0516 mL 0.2582 mL 0.5164 mL 1.2910 mL
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PIM1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIM1-IN-2477845-12-8PimPim kinasesInhibitorinhibitorinhibit

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