PIM1-IN-2
Based on 1 Customer Validation
PIM1-IN-2 is a Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 can be used in leukemia-related research .
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 477845-12-8
- Formula: C17H11ClN4O
- Molecular Weight:322.75
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PIM1 91 nM (Ki) |
PIM1-IN-2 (Compound 2) potently inhibits purified Pim-1 kinase with a Ki of 0.091 μM, and its crystallographically confirmed binding mode closely matches the predicted docking pose[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 477845-12-8
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Appearance Solid
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Molecular Weight 322.75
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Formula C17H11ClN4O
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Color Light yellow to yellow
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SMILES
NC1=NC=CC(C2=CC3=C(C4=CC=C(Cl)C=C4)ON=C3C=C2)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (61.97 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMSO : 20 mg/mL (61.97 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / DMSO | 1 mM | 3.0984 mL | 15.4919 mL | 30.9837 mL | 77.4593 mL |
| 5 mM | 0.6197 mL | 3.0984 mL | 6.1967 mL | 15.4919 mL | |
| 10 mM | 0.3098 mL | 1.5492 mL | 3.0984 mL | 7.7459 mL | |
| 15 mM | 0.2066 mL | 1.0328 mL | 2.0656 mL | 5.1640 mL | |
| 20 mM | 0.1549 mL | 0.7746 mL | 1.5492 mL | 3.8730 mL | |
| 25 mM | 0.1239 mL | 0.6197 mL | 1.2393 mL | 3.0984 mL | |
| 30 mM | 0.1033 mL | 0.5164 mL | 1.0328 mL | 2.5820 mL | |
| 40 mM | 0.0775 mL | 0.3873 mL | 0.7746 mL | 1.9365 mL | |
| 50 mM | 0.0620 mL | 0.3098 mL | 0.6197 mL | 1.5492 mL | |
| 60 mM | 0.0516 mL | 0.2582 mL | 0.5164 mL | 1.2910 mL |
PIM1-IN-2 Related Classifications
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