1. JAK/STAT Signaling
    Apoptosis
  2. Pim
    DAPK
  3. HS56

HS56 

Cat. No.: HY-123983
Handling Instructions

HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and >100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.

For research use only. We do not sell to patients.

HS56 Chemical Structure

HS56 Chemical Structure

CAS No. : 922050-57-5

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Description

HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and >100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension[1].

IC50 & Target[1]

PIM3

0.208 μM (Ki)

PIM1

2.94 μM (Ki)

PIM2

>100 μM (Ki)

In Vitro

HS56 (50 μM; 16 h) delays force onset, decreases contractile force, and reduces LC20 phosphorylation in excised rat caudal arterial VSM tissues[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: VSM tissues
Concentration: 50 μM
Incubation Time: 16 hours
Result: Modulated LC20 phosphorylation in VSM tissues.
In Vivo

HS56 (10 and 20 mg/kg; i.v.; single injection) decreases blood pressure (BP) in spontaneously hypertensive mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneously hypertensive renin transgene and wild-type (WT) mice[1]
Dosage: 10 and 20 mg/kg
Administration: Intravenous injection, single injection
Result: Induced dose-dependent decreases in systolic blood pressure.
Molecular Weight

317.75

Formula

C13H8ClN5OS

CAS No.
SMILES

N#CCSC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HS56
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HY-123983
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