BMX - BMX non-receptor tyrosine kinase Gene

Homo sapiens

Also known as ETK; PSCTK2; PSCTK3

Gene ID: 660 | Gene type: protein coding

About BMX

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,500,807-15,556,519 (from NCBI)

This gene has 5 transcripts (splice variants), 137 orthologues and 32 paralogues. Broad expression in bone marrow (RPKM 2.4), placenta (RPKM 2.2) and 21 other tissues.

Summary

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the STAT pathway, and regulates differentiation and tumorigenicity of several types of Cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

BMX Products(4)

mRNA	Protein	Name
NM_203281.3	NP_975010.1	cytoplasmic tyrosine-protein kinase BMX isoform 1
NM_001320866.2	NP_001307795.1	cytoplasmic tyrosine-protein kinase BMX isoform 2
XM_017029752.3	XP_016885241.1	cytoplasmic tyrosine-protein kinase BMX isoform X1
NM_001721.7	NP_001712.1	cytoplasmic tyrosine-protein kinase BMX isoform 1

BMX Protein Structure

BTK

SH2

Pkinase_Tyr

0
200
400
600
675 a.a.

Protein Preferred Names

Protein Names

cytoplasmic tyrosine-protein kinase BMX

BTK-like on X chromosome	Etk/Bmx cytosolic tyrosine kinase
NTK38 tyrosine kinase	bone marrow tyrosine kinase gene in chromosome X protein
epithelial and endothelial tyrosine kinase

Related Diseases

Diseases

Alias

Wet Beriberi

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia	XLA
Bruton Type Agammaglobulinemia	Bruton'S Agammaglobulinemia
Bruton-Type Agammaglobulinemia	Agmx1
Imd1	Agammaglobulinemia, X-Linked 1
Btk-Deficiency	Agammaglobulinemia
Hypogammaglobulinemia	Agammaglobulinemia, X-Linked, Type 1
Immunodeficiency 1	Bruton Agammaglobulinemia Tyrosine Kinase Deficiency
Bruton'S Agammaglobulinaemia	Bruton'S Sex-Linked Agammaglobulinemia
Bruton'S Type Agammaglobulinemia	Btk Deficiency
Agammaglobulinemia, Btk	Agammaglobulinemia, Bruton Tyrosine Kinase
Congenital Agammaglobulinemia	Immunodeficiency Type 1
X-Linked Agammaglobulinemia Type 1

Integrative Agnosia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Thiamine Deficiency Disease

Beriberi

Thiamine Deficiency	Vitamin B1 Deficiency
Aneurin Deficiency	Thiamine Vitamin Deficiency
Beriberi Nos	Beriberi Due To Vitamin B1 Deficiency
Beriberi Due To Thiamine Vitamin Deficiency	Kakkè

Cardiomyopathy, Dilated, 1gg

Dilated Cardiomyopathy 1gg	CMD1GG
Cardiomyopathy, Dilated 1gg	Cardiomyopathy, Dilated, Type 1gg

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-130574	MnTE-2-PyP chloride		≥95.0%	Phase 2
HY-111553	TAS0728	Inhibitor	99.15%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-80002	BMX-IN-1	Inhibitor	99.84%	Unkown
HY-101267	CHMFL-BMX-078	Inhibitor	≥98.0%	Unkown
HY-117900	PF-06250112	Inhibitor	/	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-117900A	(Rac)-PF-06250112		/	Unkown
HY-148585	BTK-IN-22	Inhibitor	/	Unkown
HY-148594	BTK-IN-23	Inhibitor	/	Unkown
HY-RS01557	BMX Human Pre-designed siRNA Set A		/	Unkown
HY-RS01558	Bmx Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01559	Bmx Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BMX	RGD	RGD:1565643
Canis familiaris	BMX	VGNC	VGNC:38489
Felis catus	BMX	VGNC	VGNC:60140
Mus musculus	BMX	MGD	MGI:1101778
Bos taurus	BMX	VGNC	VGNC:26529
Macaca mulatta	BMX	VGNC	VGNC:70269
Others	BMX	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.