2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. MnTE-2-PyP chloride

MnTE-2-PyP chloride  (Synonyms: BMX-010 chloride)

Cat. No.: HY-130574 Purity: ≥95.0%
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MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.

For research use only. We do not sell to patients.

MnTE-2-PyP chloride Chemical Structure

MnTE-2-PyP chloride Chemical Structure

CAS No. : 219818-60-7

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Based on 1 publication(s) in Google Scholar

MnTE-2-PyP chloride Related Antibodies

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Description

MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer[1].

In Vitro

MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation[1].
MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1].
MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment[1].
MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MnTE-2-PyP chloride Related Antibodies

Cell Viability Assay[1]

Cell Line: PC-3 cells and LNCaP cells
Concentration: 30 μM
Incubation Time:
Result: Enhanced prostate cancer cell death.

RT-PCR[1]

Cell Line: Human prostate fibroblast cells
Concentration: 30 μM
Incubation Time: 5 days
Result: Significantly decreased NOX4 mRNA expression.

Western Blot Analysis[1]

Cell Line: Human prostate fibroblast cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Inhibited NOX4 expression and restored NOX2 expression after radiation.

Immunofluorescence[1]

Cell Line: Human prostate fibroblast cells
Concentration: 30 μM
Incubation Time: 5 days
Result: Enhanced NRF2 levels.
In Vivo

MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer[1].
MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

965.12

Formula

C48H44Cl5MnN8
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

[Cl-][Mn+3]123[N-]4C5=C(C6=CC=CC=[N+]6CC)C7=[N]1C(C=C7)=C(C8=CC=CC=[N+]8CC)C9=CC=C(C(C%10=CC=CC=[N+]%10CC)=C%11[N]3=C(C=C%11)C(C%12=CC=CC=[N+]%12CC)=C4C=C5)[N-]29.[Cl-].[Cl-].[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (12.95 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0361 mL 5.1807 mL 10.3614 mL
5 mM 0.2072 mL 1.0361 mL 2.0723 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0361 mL 5.1807 mL 10.3614 mL 25.9035 mL
5 mM 0.2072 mL 1.0361 mL 2.0723 mL 5.1807 mL
10 mM 0.1036 mL 0.5181 mL 1.0361 mL 2.5904 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MnTE-2-PyP chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MnTE-2-PyP219818-60-7BMX-010BMX010BMX 010Reactive Oxygen SpeciesROSradioprotectormanganese porphyrinprostateradiation damagediabetic prostate cancerInhibitorinhibitorinhibit

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