MnTE-2-PyP chloride
MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 219818-60-7
- Formula: C48H44Cl5MnN8
- Molecular Weight:965.12
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation[1].
MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1].
MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment[1].
MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3 cells and LNCaP cells
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Concentration:30 μM
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Incubation Time:
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Result:Enhanced prostate cancer cell death.
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Cell Line:Human prostate fibroblast cells
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Concentration:30 μM
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Incubation Time:5 days
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Result:Significantly decreased NOX4 mRNA expression.
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Cell Line:Human prostate fibroblast cells
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Concentration:30 μM
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Incubation Time:24 h
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Result:Inhibited NOX4 expression and restored NOX2 expression after radiation.
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Cell Line:Human prostate fibroblast cells
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Concentration:30 μM
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Incubation Time:5 days
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Result:Enhanced NRF2 levels.
MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 219818-60-7
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Appearance Solid
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Molecular Weight 965.12
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Formula C48H44Cl5MnN8
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Color Brown to black
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SMILES
[Cl-][Mn+3]123[N-]4C5=C(C6=CC=CC=[N+]6CC)C7=[N]1C(C=C7)=C(C8=CC=CC=[N+]8CC)C9=CC=C(C(C%10=CC=CC=[N+]%10CC)=C%11[N]3=C(C=C%11)C(C%12=CC=CC=[N+]%12CC)=C4C=C5)[N-]29.[Cl-].[Cl-].[Cl-].[Cl-]
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Synonyms
BMX-010 chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 12.5 mg/mL (12.95 mM; ultrasonic and warming and heat to 80°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0361 mL | 5.1807 mL | 10.3614 mL | 25.9035 mL |
| 5 mM | 0.2072 mL | 1.0361 mL | 2.0723 mL | 5.1807 mL | |
| 10 mM | 0.1036 mL | 0.5181 mL | 1.0361 mL | 2.5904 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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