BTK-IN-48
BTK-IN-48 is a BTK inhibitor with an IC50 of 1.14 μM. BTK-IN-48 inhibits recombinant BTK and c-Src, and exerts moderate inhibitory effects on LCK, BMX/ETK, FLT3 and PIM1. BTK-IN-48 can be used in the research of B-cell malignancies and autoimmune diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3114078-55-3
- 分子式: C19H15N3O3
- 分子量:333.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BTK-IN-48 (Compound 6b) potently inhibits recombinant BTK with an IC50 of 1.14 μM, and achieves an inhibition rate of 88.6% at a single concentration of 10 μM[1].
BTK-IN-48 (10 μM) potently inhibits recombinant BTK and c-Src at a concentration of 10 μM, and exerts moderate inhibitory effects on LCK, BMX/ETK, FLT3 and PIM1[1].
BTK-IN-48 (0-40 μM; 4 days) exerts mild growth inhibition on RPMI-1788 and RPMI-7666 normal B cells, but does not induce significant cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RPMI-1788, RPMI-7666 cells
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Concentration:0, 10, 20, 30, 40 μM
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Incubation Time:4 days
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Result:Reduced viability of RPMI-1788 cells to ~60% of untreated controls at 40 μM.
Reduced viability of RPMI-7666 cells to ~85% of untreated controls at 40 μM.
Did not cause significant increase in ToPro3-positive (dead) cells across all tested concentrations, with cell death remaining below 5% for both cell lines.
化学情報
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CAS 番号 3114078-55-3
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分子量 333.34
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分子式 C19H15N3O3
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SMILES
COC(C=C1)=CC=C1N(C(C2=CC=C(O)C=C2O)=N3)C4=C3C=CC=N4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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