1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. PF-06250112

PF-06250112 

Cat. No.: HY-117900
Handling Instructions

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively.

For research use only. We do not sell to patients.

PF-06250112 Chemical Structure

PF-06250112 Chemical Structure

CAS No. : 1609465-89-5

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Description

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1].

IC50 & Target

IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]

Molecular Weight

438.43

Formula

C22H20F2N6O2

CAS No.
SMILES

O=C(N)C1=C(N(N=C1C2=CC=C(C=C2)OC3=CC=C(C=C3F)F)[[email protected]@H]4CN(CCC4)C#N)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PF-06250112
Cat. No.:
HY-117900
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