1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. PF-06250112

PF-06250112 

Cat. No.: HY-117900
Handling Instructions

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively.

For research use only. We do not sell to patients.

PF-06250112 Chemical Structure

PF-06250112 Chemical Structure

CAS No. : 1609465-89-5

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5 mg USD 160 Get quote

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Description

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1].

IC50 & Target

IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

438.43

Formula

C₂₂H₂₀F₂N₆O₂

CAS No.

1609465-89-5

SMILES

O=C(N)C1=C(N(N=C1C2=CC=C(C=C2)OC3=CC=C(C=C3F)F)[[email protected]@H]4CN(CCC4)C#N)N

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PF-06250112
Cat. No.:
HY-117900
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PF-06250112

Cat. No.: HY-117900