BMX
BMX (bone marrow tyrosine kinase on chromosome X, also called ETK) is a Tec-family non-receptor tyrosine kinase distinguished by its X-chromosomal gene location and expression in endothelial cells, myeloid cells and prostate epithelium. Like other Tec kinases it bears a pleckstrin-homology domain that binds PIP3, recruiting BMX to membranes after PI3K activation, followed by Tec-homology, SH3, SH2 and kinase domains. BMX mediates endothelial cell migration, angiogenesis, monocyte adhesion and inflammatory NO production, and in prostate cancer it is activated downstream of HER2/HER3 and supports androgen receptor signaling, growth and resistance to therapy. Because ibrutinib and related inhibitors potently inhibit BMX off-target, BMX inhibition contributes to some clinical effects of Bruton kinase inhibitors.
-
BMX Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
