1609465-89-5
1609465-89-5
Chemical Structure
PF-06250112
- CAS No.: 1609465-89-5
- Formula:C22H20F2N6O2
- Molecular Weight:438.43
IUPAC Name: (S)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazole-4-carboxamide
InChIKey: SQFDBQCBXUWICP-HNNXBMFYSA-N
SMILES: O=C(N)C1=C(N(N=C1C2=CC=C(C=C2)OC3=CC=C(C=C3F)F)[C@@H]4CN(CCC4)C#N)N
Biological Activity: PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1].
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PF-06250112 | PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. | |||||||||||||||||||||
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References
Keywords
