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Cat. No.: HY-184006

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BMX ligand-1

BMX ligand-1 (Compound 9) is a BMX ligand. BMX ligand-1 serves as a target protein ligand for the synthesis of BMX PROTAC degraders, such as IHMT-BMX-068 (HY-184005). BMX ligand-1 is applicable to prostate cancer research.

For research use only. We do not sell to patients.

CAS No.: 1863114-58-2
Formula: C₂₉H₂₆F₃N₇O₂
Molecular Weight:561.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMX ligand-1 Chemical Structure

CAS No.: 1863114-58-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	0.44 μM Compound: 12a	Antiproliferative activity against mouse BA/F3 cells assessed as cell viability after 72 hrs by CellTiter-Glo or CCK-8 assay Antiproliferative activity against mouse BA/F3 cells assessed as cell viability after 72 hrs by CellTiter-Glo or CCK-8 assay	[PMID: 26789553]
BaF3	GI₅₀	0.005 μM Compound: 12a	Inhibition of Tel-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as cell growth inhibition after 72 hrs by CellTiter-Glo or CCK-8 assay Inhibition of Tel-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as cell growth inhibition after 72 hrs by CellTiter-Glo or CCK-8 assay	[PMID: 26789553]
K562	GI₅₀	0.003 μM Compound: 12a	Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by CellTiter-Glo or CCK-8 assay Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by CellTiter-Glo or CCK-8 assay	[PMID: 26789553]

Chemical Information

CAS No. 1863114-58-2
Molecular Weight 561.56
Formula C₂₉H₂₆F₃N₇O₂
SMILES

O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)C(N)=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xia Z, et al. Discovery of Dihydropyrimido-Pyrimidine-Based Bone Marrow Tyrosine Kinase Gene in Chromosome X Protein Proteolysis-Targeting Chimeras for the Treatment of Prostate Cancer[J]. ACS Medicinal Chemistry Letters, 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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