Pim-1 kinase inhibitor 9 

Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC₅₀ value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity^[1].

Pim-1 kinase inhibitor 9 inhibits the growth of breast cancer cells T47D with IC₅₀values of 9.8 μM(8b , 48h) and 2.61 μM (8b , 96h)^[1].
Pim-1 kinase inhibitor 9 inhibits the activities of Pim-1 kinase and Pim-2 kinase with IC₅₀ values of 0.24 μM (Pim-1 kinase) and 10.53 μM (Pim-2 kinase),respectively^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pim-1 kinase inhibitor 9 (1 mg/kg/once weekly for 3 weeks; i.p.) inhibits the growth of Ehrlich solid tumours in mice by promoting caspase-3 expression and inhibiting the expression of VEGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

614.73

C₃₆H₂₄F₂N₄S₂

FC1=CC=C(C=C1)C2=CS/C(N2C3=CC=CC(N4C(C5=CC=C(C=C5)F)=CS/C4=N\C6=CC=CC=C6)=C3)=N\C7=CC=CC=C7

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• [1]. Al-Sanea MM,et al., Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166936.  [Content Brief]