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Cat. No.: HY-163119

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Pim-1 kinase inhibitor 9

Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC₅₀ value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity.

For research use only. We do not sell to patients.

Formula: C₃₆H₂₄F₂N₄S₂
Molecular Weight:614.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

Pim-1 kinase inhibitor 9 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

PIM1

0.24 μM (IC₅₀)

PIM2

10.53 μM (IC₅₀)

All Pim Isoforms :

In Vitro

Pim-1 kinase inhibitor 9 inhibits the growth of breast cancer cells T47D with IC₅₀values of 9.8 μM(8b , 48h) and 2.61 μM (8b , 96h)^[1].
Pim-1 kinase inhibitor 9 inhibits the activities of Pim-1 kinase and Pim-2 kinase with IC₅₀ values of 0.24 μM (Pim-1 kinase) and 10.53 μM (Pim-2 kinase),respectively^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

T47D
Concentration:

10 μM
Incubation Time:

48 h and 96 h
Result:

Exhibited cytotoxicity activity to T47D with IC₅₀ value of 9.8 μM (48 h) and 2.61μM (96h).

Cell Cycle Analysis^[1]

Cell Line:

T47D
Concentration:

10 μM
Incubation Time:

48 h
Result:

Inhibited cell cycle at S phase.

In Vivo

Pim-1 kinase inhibitor 9 (1 mg/kg/once weekly for 3 weeks; i.p.) inhibits the growth of Ehrlich solid tumours in mice by promoting caspase-3 expression and inhibiting the expression of VEGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

swiss albino mice/Ehrlich solid carcinoma model^[1]
Dosage:

1 mg/kg
Administration:

i.p. injected once a week, for 3 weeks
Result:

Inhibited growth of Ehrlich solid tumours in mice.

Chemical Information

Molecular Weight 614.73
Formula C₃₆H₂₄F₂N₄S₂
SMILES

FC1=CC=C(C=C1)C2=CS/C(N2C3=CC=CC(N4C(C5=CC=C(C=C5)F)=CS/C4=N\C6=CC=CC=C6)=C3)=N\C7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Al-Sanea MM,et al., Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166936. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Pim-1 kinase inhibitor 9

All Pim Isoforms