1. JAK/STAT Signaling Autophagy Apoptosis
  2. Autophagy Pim Apoptosis
  3. SGI-1776

SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively.

For research use only. We do not sell to patients.

SGI-1776 Chemical Structure

SGI-1776 Chemical Structure

CAS No. : 1173928-26-1

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Top Publications Citing Use of Products

    SGI-1776 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Feb 22;9(3):307.  [Abstract]

    PIM1 directly phosphorylated Smad2 and Smad3 and that inhibition of PIM1 kinase activity with SGI-1776 significantly reduces the protein levels of p-Smad2 and p-Smad3

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    SGI-1776 Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    SGI-1776
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    HY-13287A
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