HEXIM2 - HEXIM P-TEFb complex subunit 2 Gene

Also Known as L3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124790

Summary

This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Broad expression in testis (RPKM 8.0), kidney (RPKM 3.7) and 25 other tissues.

HEXIM2 Products (10)

mRNA Protein Name
NM_001303436.1 NP_001290365.1 protein HEXIM2 isoform 2
NM_001303437.1 NP_001290366.1 protein HEXIM2 isoform 1
NM_001303438.1 NP_001290367.1 protein HEXIM2 isoform 1
NM_001303439.1 NP_001290368.1 protein HEXIM2 isoform 1
NM_001303440.2 NP_001290369.1 protein HEXIM2 isoform 1
NM_001303441.2 NP_001290370.1 protein HEXIM2 isoform 1
NM_001303442.2 NP_001290371.1 protein HEXIM2 isoform 1
NM_001303443.2 NP_001290372.1 protein HEXIM2 isoform 1
NM_001303444.2 NP_001290373.1 protein HEXIM2 isoform 1
NM_144608.2 NP_653209.1 protein HEXIM2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 7SK snRNA binding IDA
IDA: Inferred from direct assay
19883659 GOA
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
15713662 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15713661 GOA
enables snRNA binding IDA
IDA: Inferred from direct assay
15713662 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15713662 GOA
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15713662 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15713662 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEXIM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HEXIM2 Q96MH2 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 rnps1 Homo sapiens D3DU92
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 ZNF699 Homo sapiens Q32M78
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 ZNF699 Homo sapiens Q32M78
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF699 Homo sapiens Q32M78
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 KRTAP13-3 Homo sapiens Q3SY46
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 KRTAP13-3 Homo sapiens Q3SY46
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081-3
Anti Tag CoIP
28514442
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 CTIF Homo sapiens O43310-2
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 DBF4B Homo sapiens Q8NFT6-2
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 DBF4B Homo sapiens Q8NFT6-2
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF789 Homo sapiens Q5FWF6
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF789 Homo sapiens Q5FWF6
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF500 Homo sapiens O60304
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 ZNF500 Homo sapiens O60304
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 AHCYL1 Homo sapiens O43865
Anti Tag CoIP
28514442
Intra
HEXIM2 Q96MH2 AHCYL1 Homo sapiens O43865
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 AHCYL1 Homo sapiens O43865
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 AHCYL1 Homo sapiens O43865
Anti Tag CoIP
33961781
Intra
HEXIM2 Q96MH2 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 HEXIM1 Homo sapiens O94992
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 HEXIM1 Homo sapiens O94992
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 AP2M1 Homo sapiens Q96CW1
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 AP2M1 Homo sapiens Q96CW1
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 KPNA3 Homo sapiens O00505
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF558 Homo sapiens Q96NG5
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 ZNF558 Homo sapiens Q96NG5
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF558 Homo sapiens Q96NG5
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
25416956
Intra
HEXIM2 Q96MH2 SPRY1 Homo sapiens O43609
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 SPRY1 Homo sapiens O43609
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 GATA1 Homo sapiens P15976
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 SAXO1 Homo sapiens Q8IYX7
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
25416956
Intra
HEXIM2 Q96MH2 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 RNPS1 Homo sapiens Q15287
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 RNPS1 Homo sapiens Q15287
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TADA3 Homo sapiens O75528
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 TADA3 Homo sapiens O75528
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081
Y2H
21516116
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081
Anti Tag CoIP
33961781
Intra
HEXIM2 Q96MH2 HEXIM2 Homo sapiens Q96MH2
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 HEXIM2 Homo sapiens Q96MH2
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 HEXIM2 Homo sapiens Q96MH2
Y2H
21516116
Intra
HEXIM2 Q96MH2 HEXIM2 Homo sapiens Q96MH2
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 TCF12 Homo sapiens Q99081
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 PIM1 Homo sapiens P11309
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra
HEXIM2 Q96MH2 TERF1 Homo sapiens P54274
BiFC
21044950
Intra
HEXIM2 Q96MH2 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 FAM161A Homo sapiens Q3B820
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Intra
HEXIM2 Q96MH2 ZNF426 Homo sapiens Q9BUY5
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 ZNF426 Homo sapiens Q9BUY5
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 ZNF426 Homo sapiens Q9BUY5
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
HEXIM2 Q96MH2 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
HEXIM2 Q96MH2 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra
HEXIM2 Q96MH2 CFP Homo sapiens P27918
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 CFP Homo sapiens P27918
Y2H Array
32296183
Intra
HEXIM2 Q96MH2 EGFL7 Homo sapiens Q9UHF1
Y2H Prey Pooling
32296183
Intra
HEXIM2 Q96MH2 EGFL7 Homo sapiens Q9UHF1
Validated Y2H
32296183
Intra
HEXIM2 Q96MH2 EGFL7 Homo sapiens Q9UHF1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06145 HEXIM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown