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HEXIM1 - HEXIM P-TEFb complex subunit 1 Gene

Also Known as CLP1; EDG1; HIS1; MAQ1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10614

About HEXIM1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,148,475-45,152,099 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 1 paralogue.

Summary

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

HEXIM1 Products (1)

mRNA	Protein	Name
NM_006460.3	NP_006451.1	protein HEXIM1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	12832472	GOA
enables P-TEFb complex binding	IDA IDA: Inferred from direct assay	18249148	GOA
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	14580347	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17724342	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12832472	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	28431135	GOA
enables snRNA binding	IDA IDA: Inferred from direct assay	14580347	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	14580347	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18483487	GOA
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	14580347	GOA
involved in negative regulation of viral transcription	IMP IMP: Inferred from mutant phenotype	18249148	GOA
involved in positive regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22948151	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of 7SK snRNP	IDA IDA: Inferred from direct assay	18249148	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12581153	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12581153	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEXIM1 Protein Structure

HEXIM

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
protein HEXIM1	HMBA-inducible

HEXIM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	TAP	24981860
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Bait CoIP	25470060
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	CDK9	Homo sapiens	P50750	Pull Down	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Pull Down	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18281698
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	25470060
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Fluorescence Spectr	17724342
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	17724342
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18483487
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18281698
Intra	HEXIM1	O94992	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Anti Tag CoIP	33961781
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Anti Tag CoIP	28514442
Intra	HEXIM1	O94992	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	HEXIM1	O94992	TERF2	Homo sapiens	Q15554	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163282	NB512	Inhibitor	/	Unkown
HY-RS06145	HEXIM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HEXIM1	VGNC	VGNC:62803
Macaca mulatta	HEXIM1	VGNC	VGNC:104615
Mus musculus	HEXIM1	MGD	MGI:2385923
Rattus norvegicus	HEXIM1	RGD	RGD:1559851
Bos taurus	HEXIM1	VGNC	VGNC:29826
Canis familiaris	HEXIM1	VGNC	VGNC:41670
Others	HEXIM1	NCBI