2. Gene
  3. CDK9 - cyclin dependent kinase 9 Gene

CDK9 - cyclin dependent kinase 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TAK; C-2k; CTK1; CDC2L4; PITALRE

Gene ID: 1025 | Gene type: protein coding

About CDK9

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,786,034-127,790,792 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 26 paralogues. Ubiquitous expression in ovary (RPKM 32.0), spleen (RPKM 23.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

CDK9 Products(1)

mRNA Protein Name
NM_001261.4 NP_001252.1 cyclin-dependent kinase 9

CDK9 Protein Structure

Pkinase

Pkinase: Protein kinase domain (19 - 315)

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  • 372 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 9

CDC2-related kinase

cell division cycle 2-like protein kinase 4

cell division protein kinase 9

serine/threonine protein kinase PITALRE

tat-associated kinase complex catalytic subunit

Related Diseases

Diseases Alias
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Hypothyroidism, Congenital, Nongoitrous, 6

CHNG6

Congenital Nongoitrous Hypothyroidism 6

Hypothyroidism, Congenital, Non-Goitrous, 6

Hypothyroidism, Congenital, Nongoitrous, Type 6
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Human Immunodeficiency Virus Infectious Disease

Hiv Infections
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
Charge Syndrome

Charge Association

Hall-Hittner Syndrome

Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies

Hhs

Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies

Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome

CHARGES
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.96% Yes
HY-10492 Dinaciclib Inhibitor 99.44% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
Clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Phase
HY-112088 AZD4573 Inhibitor 99.97% Phase 2
HY-101212 Fadraciclib Inhibitor 99.78% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-13914 Roniciclib Inhibitor 98.03% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-138293 SY-5609 Inhibitor 99.66% Phase 1
HY-10008 SNS-032 Inhibitor 99.51% Phase 1
HY-137478A KB-0742 dihydrochloride Inhibitor 99.24% Phase 1
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
Bioactive Molecules (83)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-103248 Toyocamycin Inhibitor 99.90% Unkown
HY-12214A NVP-2 Inhibitor 99.60% Unkown
HY-103019 Enitociclib Inhibitor 99.66% Unkown
HY-130665 TL12-186 Inhibitor 99.63% Unkown
HY-111388A SEL120-34A monohydrochloride Inhibitor 98.69% Unkown
HY-130709 PROTAC CDK2/9 Degrader-1 Inhibitor 99.85% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-123954 Casein Kinase inhibitor A51 Inhibitor 98.58% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 98.06% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.21% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-15878 LDC000067 Inhibitor 98.00% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.44% Unkown
HY-103628 PROTAC CDK9 Degrader-1 Inhibitor 98.03% Unkown
HY-12293 LY2857785 Inhibitor 99.92% Unkown
HY-16462 CDK9-IN-2 Inhibitor 99.37% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-144117 GFB-12811 Inhibitor 98.00% Unkown
HY-16559 Riviciclib hydrochloride 99.01% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.44% Unkown
HY-13033 CDK-IN-2 Inhibitor 98.97% Unkown
HY-143584 AZ5576 Inhibitor 99.88% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-103019B (-)-Enitociclib Inhibitor 99.81% Unkown
HY-111388B SEL120-34A hydrochloride Inhibitor 99.98% Unkown
HY-13231 CDK9-IN-1 Inhibitor 95.76% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-123955 Casein Kinase inhibitor A86 Inhibitor 98.47% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-12871 Atuveciclib Racemate Inhibitor 98.48% Unkown
HY-102039 CDK9-IN-8 Inhibitor 99.65% Unkown
HY-103646 CK7 Inhibitor 99.23% Unkown
HY-12843 Bohemine Inhibitor 98.93% Unkown
HY-139328 CDK12-IN-5 Inhibitor 99.01% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-153260 TP-1287 Inhibitor 95.10% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.03% Unkown
HY-130850 CDK9-IN-10 Inhibitor 98.00% Unkown
HY-124639 CDK9 inhibitor HH1 Inhibitor 97.97% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.22% Unkown
HY-162037 CDDD11-8 Inhibitor 98.74% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-111388 SEL120-34A Inhibitor / Unkown
HY-14372 BS-194 Inhibitor 99.36% Unkown
HY-13461 PHA-767491 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-130001 CDK9-IN-9 Inhibitor / Unkown
HY-131063 CDK6/9-IN-1 Inhibitor / Unkown
HY-130981 FN-1501-propionic acid / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-150562 CDK9-IN-19 Inhibitor / Unkown
HY-157980 CDK9-IN-32 Inhibitor / Unkown
HY-115714 CDK9-IN-12 Inhibitor / Unkown
HY-149962 PROTAC CDK9 degrader-5 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-112811 PROTAC CDK9 degrader-2 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-150573 CDK2-IN-12 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-145408 CDK7/9-IN-1 Inhibitor / Unkown
HY-139329 CDK12-IN-6 Inhibitor / Unkown
HY-130852 CDK9-IN-11 Inhibitor / Unkown
HY-149963 PROTAC CDK9 degrader-6 Inhibitor / Unkown
HY-147771 ZLWT-37 Inhibitor / Unkown
HY-151984 CDK9-IN-22 Inhibitor / Unkown
HY-143585 CDK9-IN-14 Inhibitor / Unkown
HY-156083 CDK9-IN-28 Inhibitor / Unkown
HY-137478 KB-0742 Inhibitor / Unkown
HY-149870 PROTAC CDK9 degrader-8 Inhibitor / Unkown
HY-155153 CDK9-IN-24 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-153426 CDK9-IN-23 Inhibitor / Unkown
HY-111356 IIIM-290 Inhibitor / Unkown
HY-161379 CLZX-205 Inhibitor / Unkown
HY-156795 PROTAC CDK9/CycT1 Degrader-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CDK9 MGD MGI:1328368
Macaca mulatta CDK9 VGNC VGNC:104886
Canis familiaris CDK9 VGNC VGNC:39062
Felis catus CDK9 VGNC VGNC:102911
Bos taurus CDK9 VGNC VGNC:27136
Rattus norvegicus CDK9 RGD RGD:1359638
Others CDK9 NCBI