CDK9 - cyclin dependent kinase 9 Gene

Also Known as TAK; C-2k; CTK1; CDC2L4; PITALRE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1025

About CDK9

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,786,034-127,790,792 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 26 paralogues. Ubiquitous expression in ovary (RPKM 32.0), spleen (RPKM 23.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

CDK9 Products (1)

mRNA	Protein	Name
NM_001261.4	NP_001252.1	cyclin-dependent kinase 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	11713533	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	16109376	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	9499409	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12037670	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	22959624	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9499409	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14701750	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	12037672	GOA
enables transcription elongation factor activity	IDA IDA: Inferred from direct assay	14580347	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	17956865	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	14701750	GOA
involved in nucleus localization	IDA IDA: Inferred from direct assay	12942536	GOA
involved in positive regulation by host of viral transcription	IDA IDA: Inferred from direct assay	10866664	GOA
involved in positive regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	29335245	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	29335245	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9499409	GOA
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	16109376	GOA
involved in regulation of DNA repair	IDA IDA: Inferred from direct assay	20493174	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	20930849	GOA
involved in regulation of mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	19575011	GOA
NOT involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19575011	GOA
involved in regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	12037670	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	20930849	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	28426094	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	14580347	GOA
involved in transcription elongation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	19844166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of P-TEFb complex	IDA IDA: Inferred from direct assay	18483487	GOA
located in PML body	IDA IDA: Inferred from direct assay	18250157	GOA
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: Inferred from direct assay	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: Inferred from physical interaction	9499409	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	14701750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9499409	GOA
part of transcription elongation factor complex	IDA IDA: Inferred from direct assay	22195968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK9 Protein Structure

Pkinase

0
100
200
300
372 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 9	CDC2-related kinase cell division cycle 2-like protein kinase 4 cell division protein kinase 9 serine/threonine protein kinase PITALRE tat-associated kinase complex catalytic subunit

CDK9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK9	P50750	CLSPN	Homo sapiens	Q9HAW4	Anti Tag CoIP	20930849
Intra	CDK9	P50750	CLSPN	Homo sapiens	Q9HAW4	Anti Bait CoIP	20930849
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	18483487
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	26659056
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	Anti Bait CoIP	20562857
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	Pull Down	32707033
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	35271311
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	TAP	23602568
Intra	CDK9	P50750	LARP7	Homo sapiens	Q4G0J3	TAP	23455922
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	33961781
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	X-Ray Diffraction	22959624
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	21729782
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	X-Ray Diffraction	18566585
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Anti Tag CoIP	21533037
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	20153263
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	TAP	24981860
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	20562857
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	TAP	23602568
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Anti Bait CoIP	18483487
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	TAP	23455922
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Protein Kinase Assay	19914168
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Pull Down	32707033
Intra	CDK9	P50750	CCNT1	Homo sapiens	O60563	Pull Down	20535204
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	20562857
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	33961781
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	TAP	23455922
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	18483487
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Pull Down	32707033
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	35271311
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Anti Tag CoIP	21533037
Intra	CDK9	P50750	HEXIM1	Homo sapiens	O94992	Anti Bait CoIP	24360279
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	Anti Tag CoIP	35271311
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	Anti Tag CoIP	21729782
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	Pull Down	32707033
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	TAP	24981860
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	Anti Tag CoIP	33961781
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	TAP	23602568
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	TAP	23455922
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583	Pull Down	9499409
Intra	CDK9	P50750	CDC37	Homo sapiens	Q16543	TAP	23455922
Intra	CDK9	P50750	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	CDK9	P50750	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	CDK9	P50750	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	35271311
Intra	CDK9	P50750	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	CDK9	P50750	CDC37	Homo sapiens	Q16543	TAP	24981860
Intra	CDK9	P50750	HSP90AA1	Homo sapiens	P07900	Lumier	25036637
Intra	CDK9	P50750	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	CDK9	P50750	HSP90AA1	Homo sapiens	P07900	TAP	23455922
Intra	CDK9	P50750	HSP90AA1	Homo sapiens	P07900	Pull Down	32707033
Intra	CDK9	P50750	FKBP5	Homo sapiens	Q13451	Lumier	25036637
Intra	CDK9	P50750	FKBP5	Homo sapiens	Q13451	TAP	24981860
Intra	CDK9	P50750	FKBP5	Homo sapiens	Q13451	TAP	23602568
Intra	CDK9	P50750	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	33961781
Intra	CDK9	P50750	FKBP5	Homo sapiens	Q13451	TAP	23455922
Intra	CDK9	P50750	FKBP5	Homo sapiens	Q13451	Pull Down	32707033
Intra	CDK9	P50750	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	CDK9	P50750	HSP90AB1	Homo sapiens	P08238	TAP	23455922
Intra	CDK9	P50750	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	CDK9	P50750	STAT3	Homo sapiens	P40763	Anti Bait CoIP	15286705
Intra	CDK9	P50750	ATRIP	Homo sapiens	Q8WXE1	Anti Bait CoIP	20930849
Intra	CDK9	P50750	ATRIP	Homo sapiens	Q8WXE1	Anti Tag CoIP	20930849
Intra	CDK9	P50750	JMJD6	Homo sapiens	Q6NYC1	Anti Tag CoIP	24360279
Intra	CDK9	P50750	JMJD6	Homo sapiens	Q6NYC1	Pull Down	24360279
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583-2	Anti Bait CoIP	9499409
Intra	CDK9	P50750	CCNT2	Homo sapiens	O60583-1	Anti Bait CoIP	9499409
Intra	CDK9	P50750	ATR	Homo sapiens	Q13535	Anti Bait CoIP	20930849
Intra	CDK9	P50750	ATR	Homo sapiens	Q13535	Anti Tag CoIP	20930849
Cross	CDK9	P50750	tat	Human immunodeficiency virus	P04608	Pull Down	20535204

Cross: Cross-species interaction Intra: Intraspecies interaction

CDK9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80614	CDK9 Antibody (YA509)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80614A	CDK9 Antibody (YA509)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P85098	CDK9 Antibody (YA4790)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Hypothyroidism, Congenital, Nongoitrous, 6	CHNG6 Congenital Nongoitrous Hypothyroidism 6 Hypothyroidism, Congenital, Non-Goitrous, 6 Hypothyroidism, Congenital, Nongoitrous, Type 6
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Charge Syndrome	Charge Association Hall-Hittner Syndrome Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies Hhs Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome CHARGES

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.80%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-112272	Lerociclib	Inhibitor	96.42%	Phase 3
HY-112088	AZD4573	Inhibitor	99.98%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-101212	Fadraciclib	Inhibitor	99.77%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Phase 2
HY-103712	Samuraciclib	Inhibitor	99.55%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Phase 2
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-10008	SNS-032	Inhibitor	99.91%	Phase 1
HY-138293	SY-5609	Inhibitor	99.93%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.75%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-111388B	Romaciclib hydrochloride	Inhibitor	99.98%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.76%	Phase 1
HY-103019B	(-)-Enitociclib	Inhibitor	99.85%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.26%	Phase 1

Pre-clinical Phase

Bioactive Molecules (157)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0400	Wogonin	Inhibitor	99.83%	Unkown
HY-103618	THZ531	Inhibitor	99.86%	Unkown
HY-12214A	NVP-2	Inhibitor	99.05%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.27%	Unkown
HY-101257	YKL-5-124	Inhibitor	99.53%	Unkown
HY-103019	Enitociclib	Inhibitor	99.89%	Unkown
HY-111388A	Romaciclib monohydrochloride	Inhibitor	99.29%	Unkown
HY-123954	BTX-A51	Inhibitor	98.58%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-130709	PROTAC CDK2/9 Degrader-1	Degrader	99.85%	Unkown
HY-130665	TL12-186	Inhibitor	99.23%	Unkown
HY-13914	Roniciclib	Inhibitor	98.00%	Unkown
HY-15878	LDC000067	Inhibitor	99.00%	Unkown
HY-143584	AZ5576	Inhibitor	99.86%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-13461	PHA-767491	Inhibitor	99.97%	Unkown
HY-173523	KI-CDK9d-32	Degrader	99.03%	Unkown
HY-103019A	(±)-Enitociclib	Inhibitor	99.23%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-16559	Riviciclib hydrochloride		99.08%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-103628	PROTAC CDK9 Degrader-1	Inhibitor	99.55%	Unkown
HY-162919	YK-2168	Inhibitor	98.05%	Unkown
HY-13231	CDK9-IN-1	Inhibitor	98.52%	Unkown
HY-12293	LY2857785	Inhibitor	99.21%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.74%	Unkown
HY-124639	CDK9 inhibitor HH1	Inhibitor	99.69%	Unkown
HY-162706	BSJ-5-63	Degrader	99.97%	Unkown
HY-169244	CDK-TCIP1	Inhibitor	98.86%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-162037	CDDD11-8	Inhibitor	99.62%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-139329	CDK12-IN-6	Inhibitor	99.15%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.94%	Unkown
HY-153260	TP-1287	Inhibitor	95.93%	Unkown
HY-18944	FIT-039	Inhibitor	99.56%	Unkown
HY-13033	CDK-IN-2	Inhibitor	99.27%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.71%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-16462	CDK9-IN-2	Inhibitor	98.72%	Unkown
HY-12871	Atuveciclib Racemate	Inhibitor	98.48%	Unkown
HY-102039	CDK9-IN-8	Inhibitor	99.16%	Unkown
HY-100950	ABC1183	Inhibitor	99.62%	Unkown
HY-111388	SEL120-34A	Inhibitor	99.49%	Unkown
HY-178861	dCDK9-202	Degrader	99.25%	Unkown
HY-111427	CDK8/19-IN-1	Inhibitor	98.08%	Unkown
HY-168518	PROTAC CDK9 degrader-9	Degrader	99.25%	Unkown
HY-126251	CDK9-IN-7	Inhibitor	98.05%	Unkown
HY-100429	CAN508	Inhibitor	99.71%	Unkown
HY-130852	CDK9-IN-11	Inhibitor	97.02%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-123955	Casein Kinase inhibitor A86	Inhibitor	99.26%	Unkown
HY-155787	SHR5428	Inhibitor	99.80%	Unkown
HY-112811	PROTAC CDK9 degrader-2	Inhibitor	99.22%	Unkown
HY-119715	AG-012986	Inhibitor	99.78%	Unkown
HY-176165	CDK9/EZH2-IN-1	Inhibitor	99.08%	Unkown
HY-115714	CDK9-IN-12	Inhibitor	99.65%	Unkown
HY-176142	YX0798	Inhibitor	98.90%	Unkown
HY-139328	CDK12-IN-5	Inhibitor	98.03%	Unkown
HY-103646	CK7	Inhibitor	99.72%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-115729	PROTAC CDK9 ligand-1	Ligand	99.75%	Unkown
HY-143585	CDK9-IN-14	Inhibitor	99.91%	Unkown
HY-12843	Bohemine	Inhibitor	98.93%	Unkown
HY-130850	CDK9-IN-10	Inhibitor	98.09%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	98.0%	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-130981	FN-1501-propionic acid		/	Unkown
HY-130001	CDK9-IN-9	Inhibitor	/	Unkown
HY-131063	CDK6/9-IN-1	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-178733	A-1592668	Inhibitor	/	Unkown
HY-147794	CDK9-IN-41	Inhibitor	98.84%	Unkown
HY-119831	Rohitukine	Inhibitor	/	Unkown
HY-150562	CDK9-IN-19	Inhibitor	/	Unkown
HY-178452	PROTAC CDK4/6/9 degrader 1	Degrader	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-176736	CDK9-IN-40	Inhibitor	/	Unkown
HY-181231	PROTAC CDK9 degrader-12	Degrader	/	Unkown
HY-173348	BLINK15	Inhibitor	/	Unkown
HY-175013	CDK6/9-IN-2	Inhibitor	/	Unkown
HY-121081A	BAY-1112054 hydrochloride	Inhibitor	/	Unkown
HY-180124	CDK8-IN-20	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown
HY-173481	CDK9-IN-37	Inhibitor	/	Unkown
HY-179023	CDK9-IN-45	Inhibitor	/	Unkown
HY-178516	PROTAC CDK4/6/9 degrader 2	Degrader	/	Unkown
HY-183698	CDK9-IN-51	Inhibitor	/	Unkown
HY-161768	VCC972839:01	Inhibitor	/	Unkown
HY-149495	CP-07	Degrader	/	Unkown
HY-180817	CDK2-IN-55	Inhibitor	98.91%	Unkown
HY-170815	CDK4/9-IN-1	Inhibitor	/	Unkown
HY-156795	PROTAC CDK9/CycT1 Degrader-2	Inhibitor	/	Unkown
HY-179375	LCI133	Inhibitor	/	Unkown
HY-178112	CDK2-IN-47	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-185339	CDK9-IN-48	Inhibitor	/	Unkown
HY-180912	HS-36	Inhibitor	/	Unkown
HY-172891	CDK9/HDAC1/HDAC3-IN-1	Inhibitor	/	Unkown
HY-181275	CDK9 ligand 4	Ligand	/	Unkown
HY-182810	CDK9 ligand 5	Ligand	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-164619	CDK9-IN-34	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-139327	CDK12-IN-4	Inhibitor	/	Unkown
HY-136841	SLM6	Inhibitor	/	Unkown
HY-168845	CDK2/9-IN-1	Inhibitor	/	Unkown
HY-157980	CDK9-IN-32	Inhibitor	/	Unkown
HY-173065	CDK9-IN-36	Inhibitor	/	Unkown
HY-151984	CDK9-IN-22	Inhibitor	/	Unkown
HY-145408	CDK7/9-IN-1	Inhibitor	/	Unkown
HY-149962	PROTAC CDK9 degrader-5	Inhibitor	/	Unkown
HY-183699	CDK9-IN-52	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-179633	ZLMT-72	Inhibitor	/	Unkown
HY-155153	CDK9-IN-24	Inhibitor	/	Unkown
HY-178039	CDK9-IN-42	Inhibitor	/	Unkown
HY-153426	CDK9-IN-23	Inhibitor	/	Unkown
HY-150573	CDK2-IN-12	Inhibitor	/	Unkown
HY-181569	CDK9-IN-46	Inhibitor	/	Unkown
HY-149870	PROTAC CDK9 degrader-8	Inhibitor	/	Unkown
HY-161379	CLZX-205	Inhibitor	/	Unkown
HY-108375	CDK9 ligand-Linker Conjugate 1	Ligand	/	Unkown
HY-150889	CDK9 ligand 1	Inhibitor	/	Unkown
HY-111356	IIIM-290	Inhibitor	/	Unkown
HY-178499	CDK9-IN-44	Inhibitor	/	Unkown
HY-185340	CDK9-IN-49	Inhibitor	/	Unkown
HY-150948	CDK12 ligand-2	Ligand	/	Unkown
HY-176451	CDK9 degrader-1	Degrader	/	Unkown
HY-173347	BLINK11	Inhibitor	/	Unkown
HY-153718	KI-ARv-03	Inhibitor	/	Unkown
HY-156083	CDK9-IN-28	Inhibitor	/	Unkown
HY-183710	CDK9-IN-50	Inhibitor	/	Unkown
HY-168896	CDK9 autophagic degrader 1	Degrader	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-147771	ZLWT-37	Inhibitor	/	Unkown
HY-170942	CDK9/PARP-IN-1	Inhibitor	/	Unkown
HY-181645	CDK12-IN-9	Inhibitor	/	Unkown
HY-149963	PROTAC CDK9 degrader-6	Inhibitor	/	Unkown
HY-177780	Cyclin K degrader 2	Degrader	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-11001A	PHA-793887 hydrochloride	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown
HY-119120	JTK-101	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDK9	MGD	MGI:1328368
Macaca mulatta	CDK9	VGNC	VGNC:104886
Canis familiaris	CDK9	VGNC	VGNC:39062
Felis catus	CDK9	VGNC	VGNC:102911
Bos taurus	CDK9	VGNC	VGNC:27136
Rattus norvegicus	CDK9	RGD	RGD:1359638
Others	CDK9	NCBI