1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK9-IN-14

CDK9-IN-14 

Cat. No.: HY-143585
Handling Instructions

CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects.

For research use only. We do not sell to patients.

CDK9-IN-14 Chemical Structure

CDK9-IN-14 Chemical Structure

CAS No. : 2650640-17-6

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Description

CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].

IC50 & Target[1]

CDK9

6.92 nM (IC50)

In Vitro

CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1]
Dosage: 5 mg/kg
Administration: p.o., qd, for 9 days
Result: Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.
Molecular Weight

419.42

Formula

C21H23F2N3O4

CAS No.
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Storage

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CDK9-IN-14
Cat. No.:
HY-143585
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