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Cat. No.: HY-191292

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PROTAC CDK9 degrader-22

PROTAC CDK9 degrader-22 is a selective CDK9 PROTAC degrader. PROTAC CDK9 degrader-22 recruits the cereblon E3 ubiquitin ligase to specifically degrade CDK9 via the ubiquitin-proteasome pathway, thereby inhibiting tumor cell proliferation. PROTAC CDK9 degrader-22 can be used in research on breast cancer, lymphoma, myeloma, leukemia, prostate cancer, and colon cancer.
(Pink: CDK9 ligand (HY-133697); Blue: Cereblon ligand (HY-103596); Black: linker (HY-W129147)).

For research use only. We do not sell to patients.

CAS No.: 2411019-97-9
Formula: C₄₂H₅₁N₉O₇
Molecular Weight:793.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PROTAC CDK9 degrader-22 Chemical Structure

CAS No.: 2411019-97-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC CDK9 degrader-22 is a selective CDK9 PROTAC degrader. PROTAC CDK9 degrader-22 recruits the cereblon E3 ubiquitin ligase to specifically degrade CDK9 via the ubiquitin-proteasome pathway, thereby inhibiting tumor cell proliferation. PROTAC CDK9 degrader-22 can be used in research on breast cancer, lymphoma, myeloma, leukemia, prostate cancer, and colon cancer^[1]. (Pink: CDK9 ligand (HY-133697); Blue: Cereblon ligand (HY-103596); Black: linker (HY-W129147)).

IC₅₀ & Target

^[1]

CDK9

Cereblon

All PROTACs Isoforms :

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-468	IC₅₀	0.093 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1
BT-549	IC₅₀	0.052 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1
OCI-Ly10	IC₅₀	0.020 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1
MM.1S	IC₅₀	0.056 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1
CCRF-CEM	IC₅₀	0.034 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1
PC-3	IC₅₀	0.087 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1
HCT-116	IC₅₀	0.310 μM	Potently inhibits cell proliferation. Potently inhibits cell proliferation.	WO2020035049A1

In Vitro

Anti-cancer

PROTAC CDK9 degrader-22 (compound C024) (4 days) exhibits potent anti-proliferative activity in MDA-MB-468, BT549, OCI-LY-10, MM.1S, CCRF-CEM, PC-3, and HCT116 cells, with IC₅₀ values of 0.093, 0.052, 0.020, 0.056, 0.034, 0.087, and 0.310 μΜ, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2411019-97-9
Molecular Weight 793.91
Formula C₄₂H₅₁N₉O₇
SMILES

CN1CCC(OC2=NC3=C(C(C)C)C=NN3C(NCC(C=C4)=CC=C4NC(CCCCCCCOC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiaohua Chen, et al. Degradation agents for cyclin dependent kinase, preparation method therefor, pharmaceutical composition thereof and use thereof. WO2020035049A1. WIPO. 2020-02-20.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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