TMX-2138
TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer.
(Pink: CDK ligand (HY-151071); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W008352)).
For research use only. We do not sell to patients.
- CAS No.: 2488892-07-3
- Formula: C40H43BrFN9O11S
- Molecular Weight:956.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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CDK1/cyclinB 8.7 nM (IC50) |
CDK2/cyclinA 10.9 nM (IC50) |
Cdk5/p25 7.0 nM (IC50) |
CDK9/cyclinT1 25.7 nM (IC50) |
CDK4/cyclinD1 901 nM (IC50) |
CDK6/cyclinD1 465 nM (IC50) |
CDK7/cyclin H 286 nM (IC50) |
Cereblon |
Chemical Information
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CAS No. 2488892-07-3
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Molecular Weight 956.79
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Formula C40H43BrFN9O11S
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SMILES
O=C(C1=C(NC2=NC(NC3=CC=C(S(=O)(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C=C3)=NC=C2Br)C=CC=C1F)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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