1. Antibody-drug Conjugate/ADC Related PROTAC
  2. ADC Linker PROTAC Linkers
  3. Boc-NH-PEG4-CH2CH2NH2

Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Boc-NH-PEG4-CH2CH2NH2 Chemical Structure

Boc-NH-PEG4-CH2CH2NH2 Chemical Structure

CAS No. : 811442-84-9

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Based on 1 publication(s) in Google Scholar

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Description

Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

Alkyl/ether

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

336.42

Formula

C15H32N2O6

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)NCCOCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥98.0%

References
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Boc-NH-PEG4-CH2CH2NH2 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Boc-NH-PEG4-CH2CH2NH2
Cat. No.:
HY-W008352
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