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Cat. No.: HY-188426

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CDK9-IN-55

CDK9-IN-55 is a CDK9 inhibitor. CDK9-IN-55 reduces POLR2A CTD phosphorylation levels and N-MYC protein levels. CDK9-IN-55 can serve as a Target protein ligand for synthesizing CDK9 PROTAC degraders, such as PROTAC CDK9 degrader-18 (HY-188425). CDK9-IN-55 exhibits anticancer activity against neuroblastoma.

For research use only. We do not sell to patients.

CAS No.: 3136219-16-1
Formula: C₂₀H₂₃ClN₆O₂S₂
Molecular Weight:479.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

CDK9-IN-55 Chemical Structure

CAS No.: 3136219-16-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CDK9

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	IC50	48.3 nM	Antiproliferative activity against IMR-32 neuroblastoma cells assessed by cell viability assay. Antiproliferative activity against IMR-32 neuroblastoma cells assessed by cell viability assay.	41818153

In Vitro

Anti-cancer

CDK9-IN-55 (Compound 7) (0.1-10 µM) dose-dependently reduces POLR2A CTD pS2 and N-MYC levels in IMR-32 neuroblastoma cells^[1].
CDK9-IN-55 inhibits IMR-32 neuroblastoma cell viability with an IC₅₀ of 48.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3136219-16-1
Molecular Weight 479.02
Formula C₂₀H₂₃ClN₆O₂S₂
SMILES

CS(C1=C(NC2=C(Cl)C=NC(N[C@H]3CC[C@H](N)CC3)=N2)C=CC(C4=NC=CS4)=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu Q, et al. DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets. Proceedings of the National Academy of Sciences of the United States of America. 2026 Mar 17;123(11):e2518248123.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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