CLZX-205
CLZX-205 (compound C-7) is a selective inhibitor of CDK9, with the IC50 of 2.9 nM. CLZX-205 plays an important role in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3033694-01-5
- Formula: C26H30N8O
- Molecular Weight:470.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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CDK9 2.9 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
0.05 μM
Compound: C-7; CLZX-205
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Growth inhibition of human HCT-116 cells incubated for 48 hrs by CCK-8 assay
Growth inhibition of human HCT-116 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 38488882] |
| HT-29 | GI50 |
0.56 μM
Compound: C-7; CLZX-205
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Growth inhibition of human HT-29 cells incubated for 48 hrs by CCK-8 assay
Growth inhibition of human HT-29 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 38488882] |
| SW480 | GI50 |
5.09 μM
Compound: C-7; CLZX-205
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Growth inhibition of human SW480 cells incubated for 48 hrs by CCK-8 assay
Growth inhibition of human SW480 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 38488882] |
Chemical Information
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CAS No. 3033694-01-5
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Molecular Weight 470.57
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Formula C26H30N8O
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SMILES
CC(N1N=NC2=C1C=C(C3=CC=NC(NC4=CC(C(N5CCCN(CC5)C)=O)=CC=N4)=C3)C=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CLZX-205 Related Classifications
HY-161379 Related Classifications
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