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Art. -Nr.: HY-161379

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CLZX-205

CLZX-205 (compound C-7) is a selective inhibitor of CDK9, with the IC₅₀ of 2.9 nM. CLZX-205 plays an important role in cancer research.

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CAS. Nr.: 3033694-01-5
Formel: C₂₆H₃₀N₈O
Molecular Weight:470.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CLZX-205 Chemical Structure

CAS. Nr.: 3033694-01-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CLZX-205 (compound C-7) is a selective inhibitor of CDK9, with the IC₅₀ of 2.9 nM. CLZX-205 plays an important role in cancer research^[1].

IC₅₀ & Target

CDK9

2.9 nM (IC₅₀)

Alle CDK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	0.05 μM Compound: C-7; CLZX-205	Growth inhibition of human HCT-116 cells incubated for 48 hrs by CCK-8 assay Growth inhibition of human HCT-116 cells incubated for 48 hrs by CCK-8 assay	[PMID: 38488882]
HT-29	GI₅₀	0.56 μM Compound: C-7; CLZX-205	Growth inhibition of human HT-29 cells incubated for 48 hrs by CCK-8 assay Growth inhibition of human HT-29 cells incubated for 48 hrs by CCK-8 assay	[PMID: 38488882]
SW480	GI₅₀	5.09 μM Compound: C-7; CLZX-205	Growth inhibition of human SW480 cells incubated for 48 hrs by CCK-8 assay Growth inhibition of human SW480 cells incubated for 48 hrs by CCK-8 assay	[PMID: 38488882]

Chemical Information

CAS. Nr. 3033694-01-5
Molecular Weight 470.57
Formel C₂₆H₃₀N₈O
SMILES

CC(N1N=NC2=C1C=C(C3=CC=NC(NC4=CC(C(N5CCCN(CC5)C)=O)=CC=N4)=C3)C=C2)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ye Zhong, et al. Identification of a Novel Selective CDK9 Inhibitor for the Treatment of CRC: Design, Synthesis, and Biological Activity Evaluation. J Med Chem. 2024 Mar 28;67(6):4739-4756. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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CLZX-205

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CLZX-205 Related Classifications

HY-161379 Related Classifications

Bioz

Keywords

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