CDK-TCIP1
Based on 1 Customer Validation
CDK-TCIP1 is a bivalent molecule linking CDK9 inhibitor SNS-032 (HY-10008) to BCL6 ligand BI3812 (HY-111381). CDK-TCIP1 potently and specifically kills BCL6-overexpressing cells with EC50 of 7.7 nM for SUDHL5 cells.
For research use only. We do not sell to patients.
- Purity: 98.68%
- CAS No.: 3008612-35-6
- Formula: C48H62ClN11O8S2
- Molecular Weight:1020.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK9 |
Chemical Information
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CAS No. 3008612-35-6
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Appearance Solid
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Molecular Weight 1020.66
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Formula C48H62ClN11O8S2
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Color White to off-white
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SMILES
CC(C)(C1=CN=C(CSC2=CN=C(NC(C3CCN(C(CCCCCCNC(C(CC4)CCN4C5=NC=C(Cl)C(NC6=CC(C=C(OCC(NC)=O)C(N7C)=O)=C7C(OC)=C6)=N5)=O)=O)CC3)=O)S2)O1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (97.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9798 mL | 4.8988 mL | 9.7976 mL | 24.4940 mL |
| 5 mM | 0.1960 mL | 0.9798 mL | 1.9595 mL | 4.8988 mL | |
| 10 mM | 0.0980 mL | 0.4899 mL | 0.9798 mL | 2.4494 mL | |
| 15 mM | 0.0653 mL | 0.3266 mL | 0.6532 mL | 1.6329 mL | |
| 20 mM | 0.0490 mL | 0.2449 mL | 0.4899 mL | 1.2247 mL | |
| 25 mM | 0.0392 mL | 0.1960 mL | 0.3919 mL | 0.9798 mL | |
| 30 mM | 0.0327 mL | 0.1633 mL | 0.3266 mL | 0.8165 mL | |
| 40 mM | 0.0245 mL | 0.1225 mL | 0.2449 mL | 0.6123 mL | |
| 50 mM | 0.0196 mL | 0.0980 mL | 0.1960 mL | 0.4899 mL | |
| 60 mM | 0.0163 mL | 0.0816 mL | 0.1633 mL | 0.4082 mL | |
| 80 mM | 0.0122 mL | 0.0612 mL | 0.1225 mL | 0.3062 mL |
CDK-TCIP1 Related Classifications
HY-169244 Related Classifications
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