CDK9-IN-45
CDK9-IN-45 (Compound B11) is a highly selective CDK9 inhibitor with IC50 values for CDK9 and CDK1 of 7.13 and 489.5 nM respectively. CDK9-IN-45 exhibits a potent inhibitory effect on colorectal cancer cells. CDK9-IN-45 induces cell apoptosis and leads to significant accumulation of ROS. CDK9-IN-45 activates Caspase-3, downregulates Mcl-1, XIAP, and c-Myc. CDK9-IN-45 can be used for research on colorectal cancer.
For research use only. We do not sell to patients.
- Formula: C25H22FN5O3
- Molecular Weight:459.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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CDK9 7.13 nM (IC50) |
CDK1 489.5 nM (IC50) |
Caspase 3 |
Mcl-1 |
XIAP |
Chemical Information
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Molecular Weight 459.47
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Formula C25H22FN5O3
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SMILES
FC1=CC=C(C2=CC=NC(NC3=CC(NN=C4C(N5CC6(COC6)C5)=O)=C4C=C3)=C2)C(OC)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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