KB-0742 hydrochloride
Based on 3 publication(s) in Google Scholar
KB-0742 hydrochloride is a potent, selective and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. KB-0742 hydrochloride is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 hydrochloride has potent anti-tumor activity.
For research use only. We do not sell to patients.
- Formula: C16H26ClN5
- Molecular Weight:323.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) KB-0742 hydrochloride
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Biological Activity
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CDK9/cyclinT1 6 nM (IC50) |
cdk2/cyclin A 397 nM (IC50) |
Cdk5/p25 1820 nM (IC50) |
CDK7/cyclin H 1510 nM (IC50) |
CDK3/Cyclin E 1420 nM (IC50) |
CDK1/cyclin A 2980 nM (IC50) |
Cdk4/cyclin D1 3130 nM (IC50) |
CDK6/cycD1 3950 nM (IC50) |
CDK8/cyclin C >10000 nM (IC50) |
Chemical Information
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Molecular Weight 323.86
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Formula C16H26ClN5
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SMILES
CCC(C1=NC2=CC=NN2C(N[C@@H]3C[C@H](CC3)N)=C1)CC.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Freeman DB, et al. Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J Med Chem. 2023 Dec 14;66(23):15629-15647. [Content Brief]
[2]. André Richters, et al. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chem Biol. 2020 Oct 20;S2451-9456(20)30380-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KB-0742 hydrochloride Related Classifications
HY-137478B Related Classifications
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