KB-0742 hydrochloride
Based on 3 publication(s) in Google Scholar
KB-0742 hydrochloride is a potent, selective and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. KB-0742 hydrochloride is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 hydrochloride has potent anti-tumor activity.
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- Formule: C16H26ClN5
- Masse moléculaire:323.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) KB-0742 hydrochloride
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Activité biologique
Description
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CDK9/cyclinT1 6 nM (IC50) |
cdk2/cyclin A 397 nM (IC50) |
Cdk5/p25 1820 nM (IC50) |
CDK7/cyclin H 1510 nM (IC50) |
CDK3/Cyclin E 1420 nM (IC50) |
CDK1/cyclin A 2980 nM (IC50) |
Cdk4/cyclin D1 3130 nM (IC50) |
CDK6/cycD1 3950 nM (IC50) |
CDK8/cyclin C >10000 nM (IC50) |
Chemical Information
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Masse moléculaire 323.86
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Formule C16H26ClN5
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SMILES
CCC(C1=NC2=CC=NN2C(N[C@@H]3C[C@H](CC3)N)=C1)CC.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Freeman DB, et al. Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J Med Chem. 2023 Dec 14;66(23):15629-15647. [Content Brief]
[2]. André Richters, et al. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chem Biol. 2020 Oct 20;S2451-9456(20)30380-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KB-0742 hydrochloride Related Classifications
HY-137478B Related Classifications
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