2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. ZLWT-37

ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells.

For research use only. We do not sell to patients.

ZLWT-37

ZLWT-37 Chemical Structure

CAS No. : 2813347-44-1

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ZLWT-37 Related Antibodies

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Description

ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells[1].

IC50 & Target

CDK9

0.002 μM (IC50)

CDK2

0.054 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 GI50
0.051 μM
Compound: ZLWT-37
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 36054949]
HCT-116 GI50
0.029 μM
Compound: ZLWT-37
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 36054949]
MCF7 GI50
0.109 μM
Compound: ZLWT-37
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 36054949]
SW480 GI50
0.328 μM
Compound: ZLWT-37
Antiproliferative activity against human SW480 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as cell growth inhibition after 72 hrs by MTT assay
[PMID: 36054949]
In Vitro

ZLWT-37 shows antiproliferative activity with a GI50 of 0.029 μM for HCT116[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZLWT-37 Related Antibodies
In Vivo

ZLWT-37 (0-20 mg/kg; p.o.; once daily for 14 consecutive days) shows potential efficacy against the growth of implanted HCT116 cells in mice without obvious toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

464.00

Formula

C26H30ClN5O
CAS No.
SMILES

N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZLWT-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLWT-372813347-44-1ZLWT37ZLWT 37CDKApoptosisCyclin dependent kinaseAChECDK9CDK2anti-cancerHCT116low toxicityInhibitorinhibitorinhibit

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