2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. ZLWT-37

ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells.

For research use only. We do not sell to patients.

ZLWT-37 Chemical Structure

ZLWT-37 Chemical Structure

CAS No. : 2813347-44-1

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ZLWT-37 Related Antibodies

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Description

ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells[1].

IC50 & Target

CDK9

0.002 μM (IC50)

CDK2

0.054 μM (IC50)

In Vitro

ZLWT-37 shows antiproliferative activity with a GI50 of 0.029 μM for HCT116[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZLWT-37 Related Antibodies
In Vivo

ZLWT-37 (0-20 mg/kg; p.o.; once daily for 14 consecutive days) shows potential efficacy against the growth of implanted HCT116 cells in mice without obvious toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

464.00

Formula

C26H30ClN5O
CAS No.
SMILES

N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZLWT-37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLWT-372813347-44-1ZLWT37ZLWT 37CDKApoptosisCyclin dependent kinaseAChECDK9CDK2anti-cancerHCT116low toxicityInhibitorinhibitorinhibit

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