2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. CDK Aurora Kinase Apoptosis
  4. CDK2-IN-55

CDK2-IN-55 (Compound 12c) is a CDK2 inhibitor with an IC50 value of 4.7 nM. CDK2-IN-55 also has a strong inhibitory effect on CDK1 (IC50 = 26.3 nM), moderate inhibitory effects on Aurora A (IC50 = 92.0 nM) and CDK9 (IC50 = 288 nM), and very weak inhibitory activities on CDK4, CDK6, DYRK1A, and GSK3β (IC50 > 1000 nM). CDK2-IN-55 shows strong anti-proliferative activity against various cancer cell lines, inducing cell cycle arrest and apoptosis. CDK2-IN-55 can be used for research on colorectal cancer, lung cancer, and cervical cancer.

For research use only. We do not sell to patients.

CDK2-IN-55

CDK2-IN-55 Chemical Structure

CAS No. : 3099101-44-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

CDK2-IN-55 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

View All Aurora Kinase Isoform Specific Products:

View All Isoforms
Aurora Kinase Aurora A Aurora B Aurora C

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Description

CDK2-IN-55 (Compound 12c) is a CDK2 inhibitor with an IC50 value of 4.7 nM. CDK2-IN-55 also has a strong inhibitory effect on CDK1 (IC50 = 26.3 nM), moderate inhibitory effects on Aurora A (IC50 = 92.0 nM) and CDK9 (IC50 = 288 nM), and very weak inhibitory activities on CDK4, CDK6, DYRK1A, and GSK3β (IC50 > 1000 nM). CDK2-IN-55 shows strong anti-proliferative activity against various cancer cell lines, inducing cell cycle arrest and apoptosis. CDK2-IN-55 can be used for research on colorectal cancer, lung cancer, and cervical cancer[1].

IC50 & Target[1]

CDK2

4.7 nM (IC50)

CDK1

26.3 nM (IC50)

CDK9

288 nM (IC50)

Aurora A

92 nM (IC50)

Molecular Weight

416.52

Formula

C18H20N6O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C=N1)=C(NC2=NC3=C(CCCC3)S2)N=C1NC4=CC=C(S(N)(=O)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4008 mL 12.0042 mL 24.0085 mL
5 mM 0.4802 mL 2.4008 mL 4.8017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4008 mL 12.0042 mL 24.0085 mL 60.0211 mL
5 mM 0.4802 mL 2.4008 mL 4.8017 mL 12.0042 mL
10 mM 0.2401 mL 1.2004 mL 2.4008 mL 6.0021 mL
15 mM 0.1601 mL 0.8003 mL 1.6006 mL 4.0014 mL
20 mM 0.1200 mL 0.6002 mL 1.2004 mL 3.0011 mL
25 mM 0.0960 mL 0.4802 mL 0.9603 mL 2.4008 mL
30 mM 0.0800 mL 0.4001 mL 0.8003 mL 2.0007 mL
40 mM 0.0600 mL 0.3001 mL 0.6002 mL 1.5005 mL
50 mM 0.0480 mL 0.2401 mL 0.4802 mL 1.2004 mL
60 mM 0.0400 mL 0.2001 mL 0.4001 mL 1.0004 mL
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CDK2-IN-55 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-553099101-44-4CDKAurora KinaseApoptosisCyclin dependent kinaseCycloalkyl-fused thiazolePyrimidinesAntiproliferative activityCDK2 inhibitorsCell cycle arrestInhibitorinhibitorinhibit

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