Aurora Kinase Inhibitors

Aurora Kinase

Aurora A

Aurora B

Aurora C

Aurora Kinase Inhibitors

Product Name	Aurora Kinase	Aurora A	Aurora B	Aurora C	Purity
Alisertib		Aurora A, IC₅₀: 1.2 nM	Aurora B, IC₅₀: 396.5 nM		99.84%
Barasertib-HQPA			Aurora B, IC₅₀: 0.37 nM		99.47%
Barasertib			Aurora B, IC₅₀: 0.37 nM		99.73%
Reversine		Aurora A, IC₅₀: 400 nM	Aurora B, IC₅₀: 500 nM	Aurora C, IC₅₀: 400 nM	99.22%
Tozasertib		Aurora A, Ki: 0.6 nM	Aurora B, Ki: 18 nM	Aurora C, Ki: 4.6 nM	99.94%
JNJ-7706621		Aurora A, IC₅₀: 11 nM	Aurora B, IC₅₀: 15 nM		99.91%
AT9283		Aurora A, IC₅₀: 3 nM	Aurora B, IC₅₀: 3 nM		99.70%
Hesperadin			Aurora B, IC₅₀: 250 nM		98.00%
KW-2449		Aurora A, IC₅₀: 48 nM			99.69%
MK-5108		Aurora A, IC₅₀: 64 pM			99.89%
AMG 900		Aurora A, IC₅₀: 5 nM	Aurora B, IC₅₀: 4 nM	Aurora C, IC₅₀: 1 nM	99.05%
GSK-1070916			Aurora B, Ki: 0.38 nM	Aurora C, Ki: 1.5 nM	99.55%
Danusertib		Aurora A, IC₅₀: 13 nM	Aurora B, IC₅₀: 79 nM	Aurora C, IC₅₀: 61 nM	99.44%
ZM-447439		Aurora A, IC₅₀: 110 nM	Aurora B, IC₅₀: 130 nM		99.19%
LY3295668		Aurora A, IC₅₀: 0.8 nM			98.88%
PF-03814735		Aurora 1, IC₅₀: 0.8 nM	Aurora 2, IC₅₀: 5 nM		99.58%
MLN8054		Aurora A, IC₅₀: 4 nM			99.54%
JB170		Aurora A, DC₅₀: 28 nM Aurora A, Kd: 99 nM Aurora A, EC₅₀: 193 nM			98.40%
TAK-901		Aurora A, IC₅₀: 21 nM	Aurora B, IC₅₀: 15 nM		99.84%
BI-847325				Aurora C, IC₅₀: 15 nM	98.66%
XL228		Aurora A, IC₅₀: 3.1 nM			99.29%
CYC-116		Aurora A, Ki: 8 nM	Aurora B, Ki: 9.2 nM		98.17%
SP-96		Aurora A, IC₅₀: 18.975 nM	Aurora B, IC₅₀: 0.316 nM		99.42%
SNS-314 mesylate		Aurora A, IC₅₀: 9 nM	Aurora B, IC₅₀: 31 nM	Aurora C, IC₅₀: 6 nM	99.53%
TCS7010		Aurora A, IC₅₀: 3.4 nM	Aurora B, IC₅₀: 3.4 μM		99.61%
ENMD-2076		Aurora A, IC₅₀: 14 nM			99.12%
PF 477736		Aurora-A, IC₅₀: 23 nM			99.21%
CCT 137690		Aurora A, IC₅₀: 15 nM	Aurora B, IC₅₀: 25 nM	Aurora C, IC₅₀: 19 nM	99.54%
GW779439X		Aurora A			99.85%
Ilorasertib hydrochloride		Aurora A, IC₅₀: 120 nM	Aurora B, IC₅₀: 7 nM Aurora B (Y156H), IC₅₀: 12 nM	Aurora C, IC₅₀: 1 nM	99.67%
SCH-1473759 hydrochloride		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM		99.79%
MK-8745		Aurora A, IC₅₀: 0.6 nM			99.49%
Chiauranib			Aurora B, IC₅₀: 9 nM		99.28%
CCT129202		Aurora A, IC₅₀: 42 nM	Aurora B, IC₅₀: 198 nM	Aurora C, IC₅₀: 227 nM	≥98.0%
PHA-680632		Aurora A, IC₅₀: 27 nM	Aurora B, IC₅₀: 135 nM	Aurora C, IC₅₀: 120 nM	98.48%
Cenisertib		Aurora-A	Aurora-B		99.64%
TAS-119		Aurora A, IC₅₀: 1 nM	Aurora B, IC₅₀: 95 nM		98.03%
NU6140		Aurora A, IC₅₀: 67 nM	Aurora B, IC₅₀: 35 nM		99.07%
ENMD-2076 Tartrate		Aurora A, IC₅₀: 1.86 nM			99.42%
DB0614	Aurora Kinase				98.80%
GSK2646264		Aurora A, pIC₅₀: <4.3	Aurora B, pIC₅₀: <4.6		98.39%
Aurora kinase inhibitor-3		Aurora A, IC₅₀: 42 nM			99.34%
dAURK-4 hydrochloride		Aurora A			99.44%
AKI603		Aurora A, IC₅₀: 12.3 nM			98.03%
CD532		Aurora A, IC₅₀: 45 nM			98.78%
Aurora kinase inhibitor-2		Aurora A, IC₅₀: 310 nM	Aurora B, IC₅₀: 240 nM		99.19%
TC-A 2317 hydrochloride		Aurora A, Ki: 1.2 nM	Aurora B, Ki: 101 nM
Phthalazinone pyrazole		Aurora-A, IC₅₀: 0.031 μM			≥98.0%
Ilorasertib		Aurora A, IC₅₀: 120 nM	Aurora B, IC₅₀: 7 nM Aurora B (Y156H), IC₅₀: 12 nM	Aurora C, IC₅₀: 1 nM	≥98.0%
SCH-1473759		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM		98.20%
Alisertib sodium		Aurora A, IC₅₀: 12.5 nM	Aurora B, IC₅₀: 396.5 nM
Hesperadin hydrochloride			Aurora B, IC₅₀: 250 nM
Aurora inhibitor 1		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM
dAURK-4		Aurora A
Aurora A inhibitor 2		Aurora A, IC₅₀: 21.94 nM	Aurora B, IC₅₀: 273.18 nM
RET-IN-19		Aurora A, IC₅₀: 0.242 ± 0. μM	Aurora B, IC₅₀: 0.536 ± 45 μM
SNS-314		Aurora A, IC₅₀: 9 nM	Aurora B, IC₅₀: 31 nM	Aurora C, IC₅₀: 6 nM
Aurora kinase inhibitor-10			Aurora B, IC₅₀: 8 nM
Glycyl H-1152 hydrochloride		Aurora A, IC₅₀: 2.35 μM
Aurora A/PKC-IN-1		Aurora A, IC₅₀: 6.9 nM
Aurora Kinases-IN-2		Aurora A, IC₅₀: 90 nM	Aurora B, IC₅₀: 152 nM
Aurora kinase inhibitor-9		Aurora A, IC₅₀: 0.093 μM	Aurora B, IC₅₀: 0.09 μM
AT9283 lactic acid		Aurora A, IC₅₀: 3 nM	Aurora B, IC₅₀: 3 nM
Aurora B inhibitor 1			Aurora B, Ki: 0.01 μM

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