IIIM-290

Art. -Nr.: HY-111356: Data Sheet Handling Instructions
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IIIM-290 is a potent and oral CDK inhibitor with IC₅₀s of 90 and 94 nM for CDK2/A and CDK9/T1.

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IIIM-290 Chemische Struktur

CAS. Nr. : 2213468-64-3

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle CDK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IIIM-290 is a potent and oral CDK inhibitor with IC₅₀s of 90 and 94 nM for CDK2/A and CDK9/T1.

IC₅₀ & Target^[1]

CDK2/A

90 nM (IC₅₀)

CDK9/T1

94 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	6 μM Compound: 11d	Growth inhibition of human 786-0 cells after 48 hrs by MTT assay Growth inhibition of human 786-0 cells after 48 hrs by MTT assay	[PMID: 29370702]
A-431	GI₅₀	8 μM Compound: 11d	Growth inhibition of human A431 cells after 48 hrs by MTT assay Growth inhibition of human A431 cells after 48 hrs by MTT assay	[PMID: 29370702]
A549	GI₅₀	4 μM Compound: 11d	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 29370702]
BT-549	GI₅₀	5 μM Compound: 11d	Growth inhibition of human BT549 cells after 48 hrs by MTT assay Growth inhibition of human BT549 cells after 48 hrs by MTT assay	[PMID: 29370702]
Caco-2	GI₅₀	7 μM Compound: 11d	Growth inhibition of human Caco2 cells after 48 hrs by MTT assay Growth inhibition of human Caco2 cells after 48 hrs by MTT assay	[PMID: 29370702]
COLO 205	GI₅₀	7 μM Compound: 11d	Growth inhibition of human COLO205 cells after 48 hrs by MTT assay Growth inhibition of human COLO205 cells after 48 hrs by MTT assay	[PMID: 29370702]
DU-145	GI₅₀	5 μM Compound: 11d	Growth inhibition of human DU145 cells after 48 hrs by MTT assay Growth inhibition of human DU145 cells after 48 hrs by MTT assay	[PMID: 29370702]
HCT-116	GI₅₀	5 μM Compound: 11d	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 29370702]
HCT-116	GI₅₀	9.32 μM Compound: 1e; IIIM-290	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
HEK293	GI₅₀	>100 μM Compound: 1e; IIIM-290	Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
HEK293	GI₅₀	22 μM Compound: 11d	Growth inhibition of human HEK293 cells after 48 hrs by MTT assay Growth inhibition of human HEK293 cells after 48 hrs by MTT assay	[PMID: 29370702]
HEK293	IC₅₀	>50 μM Compound: 11d	Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method	[PMID: 29370702]
HL-60	GI₅₀	0.9 μM Compound: 11d	Growth inhibition of human HL60 cells after 48 hrs by MTT assay Growth inhibition of human HL60 cells after 48 hrs by MTT assay	[PMID: 29370702]
HOP-62	GI₅₀	7 μM Compound: 11d	Growth inhibition of human HOP62 cells after 48 hrs by MTT assay Growth inhibition of human HOP62 cells after 48 hrs by MTT assay	[PMID: 29370702]
HOP-92	GI₅₀	3 μM Compound: 11d	Growth inhibition of human HOP92 cells after 48 hrs by MTT assay Growth inhibition of human HOP92 cells after 48 hrs by MTT assay	[PMID: 29370702]
LOX IMVI	GI₅₀	4 μM Compound: 11d	Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay Growth inhibition of human LOXIMVI cells after 48 hrs by MTT assay	[PMID: 29370702]
MCF7	GI₅₀	4 μM Compound: 11d	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 29370702]
MDA-MB-231	GI₅₀	4 μM Compound: 11d	Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29370702]
MDA-MB-468	GI₅₀	4 μM Compound: 11d	Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay Growth inhibition of human MDA-MB-468 cells after 48 hrs by MTT assay	[PMID: 29370702]
MIA PaCa-2	GI₅₀	1 μM Compound: 11d	Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay	[PMID: 29370702]
MIA PaCa-2	GI₅₀	1.94 μM Compound: 1e; IIIM-290	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37302342]
MOLT-4	GI₅₀	0.5 μM Compound: 11d	Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay Growth inhibition of human MOLT4 cells after 48 hrs by MTT assay	[PMID: 29370702]
NCI-H226	GI₅₀	4 μM Compound: 11d	Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H226 cells after 48 hrs by MTT assay	[PMID: 29370702]
NCI-H522	GI₅₀	5 μM Compound: 11d	Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H522 cells after 48 hrs by MTT assay	[PMID: 29370702]
OVCAR-3	GI₅₀	8 μM Compound: 11d	Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay Growth inhibition of human OVCAR3 cells after 48 hrs by MTT assay	[PMID: 29370702]
OVCAR-4	GI₅₀	9 μM Compound: 11d	Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay Growth inhibition of human OVCAR4 cells after 48 hrs by MTT assay	[PMID: 29370702]
OVCAR-5	GI₅₀	7 μM Compound: 11d	Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay Growth inhibition of human OVCAR5 cells after 48 hrs by MTT assay	[PMID: 29370702]
PANC-1	GI₅₀	4 μM Compound: 11d	Growth inhibition of human PANC1 cells after 48 hrs by MTT assay Growth inhibition of human PANC1 cells after 48 hrs by MTT assay	[PMID: 29370702]
PC-3	GI₅₀	3 μM Compound: 11d	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 29370702]
T47D	GI₅₀	6 μM Compound: 11d	Growth inhibition of human T47D cells after 48 hrs by MTT assay Growth inhibition of human T47D cells after 48 hrs by MTT assay	[PMID: 29370702]

Molekulargewicht

462.32

Formel

C₂₃H₂₁Cl₂NO₅

CAS. Nr.

2213468-64-3

SMILES

OC1=C2C(OC(/C=C/C3=C(Cl)C=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)CN(C)CC4)C(O)=C1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bharate SB, et al. Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J Med Chem. 2018 Feb 22;61(4):1664-1687. [Content Brief]

IIIM-290 Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IIIM-2902213468-64-3IIIM290IIIM 290CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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IIIM-290

IIIM-290 Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle CDK Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

IIIM-290 Related Classifications

Molaritätsrechner

Verdünnungsrechner