1. Cell Cycle/DNA Damage
  2. CDK
  3. NVP-2

NVP-2 

Cat. No.: HY-12214A Purity: 99.29%
Handling Instructions

NVP-2 is a CDK9 inhibitor with an IC50 of 0.5 nM.

For research use only. We do not sell to patients.

NVP-2 Chemical Structure

NVP-2 Chemical Structure

CAS No. : 1263373-43-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 474 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 720 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3840 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    NVP-2 purchased from MCE. Usage Cited in: Cell. 2018 Sep 20;175(1):171-185.e25.

    WB analysis of MV4-11 cells treated with BTX161 (6 hr), iCDK9 (4 hr), or THZ1 (4 hr) at the indicated concentrations in different combinations as indicated. PP2Ac is a loading control.

    NVP-2 purchased from MCE. Usage Cited in: Neoplasia (2019) 21, 713-720.

    LNCaP cells were treated with DMSO or increasing dose of NVP2 for 24 hours and samples are analyzed using western blotting. Densitometry is used to evaluate the abundance of each protein.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    NVP-2 is a CDK9 inhibitor with an IC50 of 0.5 nM.

    IC50 & Target

    CDK9

    0.5 nM (IC50)

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (194.91 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9491 mL 9.7453 mL 19.4905 mL
    5 mM 0.3898 mL 1.9491 mL 3.8981 mL
    10 mM 0.1949 mL 0.9745 mL 1.9491 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Molecular Weight

    513.07

    Formula

    C₂₇H₃₇ClN₆O₂

    CAS No.

    1263373-43-8

    SMILES

    ClC1=CN=C(N[[email protected]]2CC[[email protected]](N[[email protected]](C)COC)CC2)C=C1C3=CC=CC(NCC4(C#N)CCOCC4)=N3

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.29%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    NVP-2
    Cat. No.:
    HY-12214A
    Quantity:

    NVP-2

    Cat. No.: HY-12214A