CDK5-IN-4
CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research.
For research use only. We do not sell to patients.
- CAS No.: 1212711-91-5
- Formula: C24H24FN5O3
- Molecular Weight:449.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GSK-3α 0.98 ± 0.0 μM (IC50) |
GSK-3β 4.00 ± 1.3 μM (IC50) |
CDK9 1.76 ± 0.3 μM (IC50) |
CDK2 6.24 ± 2.8 μM (IC50) |
CDK5 9.8 ± 2.29 μM (IC50) |
Chemical Information
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CAS No. 1212711-91-5
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Molecular Weight 449.48
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Formula C24H24FN5O3
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SMILES
O=C(N[C@H]1CO[C@@H]2[C@H](CO[C@H]12)NC3=NC(C4=CC=CC(F)=C4)=CC=N3)NCC5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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